clm-qt3vte05ek

CEA (central amygdaloid nucleus) functionally connects to ACB (Nucleus accumbens)

Species: Rat
Result: ambiguous
Method: optogenetic circuit mapping
Sign: unknown
Evidence: Because viral injection could spill into the adjacent central amygdala, the authors tested whether GABAergic input contributed to the light-evoked accumbens responses; picrotoxin reduced the responses only marginally (about 7% in 22 cells from 4 rats), which they took as evidence against a functional contribution of central amygdala fibres, though the connection itself was not directly assayed.
Source: Maturation of silent synapses in amygdala-accumbens projection contributes to incubation of cocaine craving
Nature Neuroscience, 2013
DOI 10.1038/nn.3533 · PubMed 24077564 · PMC3815713, Results, 'Recording of BLA-to-NAc shell excitatory synapses'
Named in the paper: “central nucleus (CeA)” and “NAc”
Made by: an AI model reading the paper (claude-opus-5, extract@0.3.0), 2026-10-09
Checked by: a second AI model (claude-opus-5) is unsure, 2026-10-09
“The picrotoxin test only shows negligible GABAergic contribution and the no-CeA-projection statement is cited from prior work, so whether 'ambiguous' is the paper's own result is unclear.”
Status: proposed
Drafted and checked by AI models; it stays proposed until people have audited a sample of such claims.