clm-r1j4f0s8dz

PL (Prelimbic area) functionally connects to DR (Dorsal nucleus raphe)

Species: Rat
Result: present
Method: optogenetic circuit mapping
Sign: excitatory
Evidence: In slices with ChR2 in mPFC and DRN neurons retrogradely labelled from the central amygdala, photostimulation of mPFC fibres evoked monosynaptic excitatory currents (TTX-sensitive, rescued by 4-AP) in CeA-projecting 5-HT neurons, with mean amplitude near 49 pA in both control and prenatal-ethanol rats; paired-pulse ratio was lower after prenatal ethanol and SNAP enhanced the currents in controls.
Source: Chemogenetic inhibition of prefrontal cortex inputs to dorsal raphe reduces anxiety behaviors in male rat model of fetal alcohol spectrum disorder
Scientific Reports, 2025
DOI 10.1038/s41598-025-99181-8 · PubMed 40275074 · PMC12022358, Fig. 5A–D; Fig. 6D–E
Licence: CC-BY-NC-ND-4.0
Named in the paper: “mPFC” and “DRNCeA 5-HT neurons”
Made by: an AI model reading the paper (claude-opus-5, extract@0.3.0), 2026-10-09
Checked by: a second AI model (claude-opus-5) agrees, 2026-10-09
“Matches Fig. 5A–D and 6D–E: monosynaptic mPFC input, ~49 pA both groups, lower PPR in PE, SNAP effect in controls.”
Status: proposed
Drafted and checked by AI models; it stays proposed until people have audited a sample of such claims.