clm-rd36w52fwq
PVT (Paraventricular nucleus of the thalamus) functionally connects to ACB (Nucleus accumbens)
All claims for this connection- Species
- Mouse
- Result
- present
- Method
- optogenetic circuit mapping
- Sign
- excitatory
- Evidence
- Optically evoked excitatory postsynaptic currents from PVT terminals were also recorded in accumbens D1 medium spiny neurons; these responses were unchanged by 1 Hz optical low-frequency stimulation (about 104% of baseline, n = 9 neurons from 3 mice) and their AMPA/NMDA ratio was unaltered by morphine withdrawal.
- Source
Nucleus accumbens D1/D2 circuits control opioid withdrawal symptoms in mice
Journal of Clinical Investigation, 2023
DOI 10.1172/jci163266 · PubMed 37561576 · PMC10503809, Fig. 4B; Fig. 5CLicence: CC-BY-4.0
- Named in the paper
- “PVT” and “NAc D1 MSNs”
- Made by
- an AI model reading the paper (claude-opus-5, extract@0.3.0), 2026-10-09
- Checked by
a second AI model (claude-opus-5) agrees, 2026-10-09
“PVT-evoked EPSCs in D1 MSNs were unchanged by oLFS (104.2%, n=9/3) and A/N change was specific to D2.”
- Status
proposed
Drafted and checked by AI models; it stays proposed until people have audited a sample of such claims.