clm-rp4jgxep96
SUB (Subiculum) functionally connects to ACB (Nucleus accumbens)
All claims for this connection- Species
- Mouse
- Result
- present
- Method
- optogenetic circuit mapping
- Sign
- excitatory
- Evidence
- Blue-light stimulation of ChR2-expressing vHIP terminals in NAc shell slices reliably evoked EPSCs in accumbens medium spiny neurons (including paired-pulse and 1 Hz/4 Hz trains), and the optically evoked currents were abolished by glutamate receptor antagonists, indicating a glutamatergic vHIP-to-NAc connection.
- Source
Ventral hippocampal afferents to the nucleus accumbens regulate susceptibility to depression
Nature Communications, 2015
DOI 10.1038/ncomms8062 · PubMed 25952660 · PMC4430111, Fig. 1m,n; Fig. 2b; Fig. 3b; Supplementary Fig. 2cLicence: CC-BY-4.0
- Named in the paper
- “vHIP (ventral subiculum)” and “NAc shell”
- Made by
- an AI model reading the paper (claude-opus-5, extract@0.3.0), 2026-10-09
- Checked by
a second AI model (claude-opus-5) agrees, 2026-10-09
“vHIP terminal stimulation evoked glutamate-receptor-dependent EPSCs in NAc shell MSNs as cited.”
- Status
proposed
Drafted and checked by AI models; it stays proposed until people have audited a sample of such claims.