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PVH (Paraventricular hypothalamic nucleus) functionally connects to CEA (Central amygdalar nucleus)

Species: Mouse
Result: present
Method: optogenetic circuit mapping
Sign: modulatory
Evidence: Blue-light stimulation of ChR2-expressing PVN oxytocin neuron terminals in the central amygdala raised c-Fos expression in CeA neurons and reduced pain-induced anxiety-like behavior; intra-CeA oxytocin receptor antagonist blocked the behavioral effect of activating PVN oxytocin cells, indicating peptidergic modulatory transmission.
Source: Paraventricular nucleus‐central amygdala oxytocinergic projection modulates pain‐related anxiety‐like behaviors in mice
CNS Neuroscience & Therapeutics, 2023
DOI 10.1111/cns.14282 · PubMed 37248645 · PMC10580334, Fig. 6A,G,H; Fig. 5I–N
Licence: CC-BY-4.0
Named in the paper: “PVN” and “CeA”
Made by: an AI model reading the paper (claude-opus-5, extract@0.3.0), 2026-10-09
Checked by: a second AI model (claude-opus-5) agrees, 2026-10-09
“Optogenetic terminal activation in CeA increased CeA c-Fos and OTA in CeA blocked effects, consistent with modulatory oxytocinergic transmission.”
Status: proposed
Drafted and checked by AI models; it stays proposed until people have audited a sample of such claims.