clm-sg7ghpcevy

BLA (Basolateral amygdalar nucleus) functionally connects to CEAl somatostatin-expressing neurons

Species: Mouse
Result: present
Method: optogenetic circuit mapping
Sign: excitatory
Evidence: Blue-light activation of ChR2-expressing BLA axons in slices evoked excitatory postsynaptic currents with AMPA and NMDA components in patched CeL somatostatin neurons. Peak currents trended larger and the AMPA/NMDA ratio was higher in SOM-PTEN-KO mice, while paired-pulse ratio did not change.
Source: PTEN in somatostatin neurons regulates fear and anxiety and is required for inhibitory synaptic connectivity within central amygdala
Frontiers in Cellular Neuroscience, 2025
DOI 10.3389/fncel.2025.1597131 · PubMed 40642101 · PMC12240933, Fig. 2a-d; Results 2.2
Licence: CC-BY-4.0
Named in the paper: “basolateral amygdala (BLA)” and “CeL SOM+ neurons”
Made by: an AI model reading the paper (claude-opus-5-5, extract@0.3.0), 2026-10-10
Checked by: a second AI model (claude-opus-5-5) agrees, 2026-10-10
“ChR2-expressing BLA terminals evoked excitatory currents in CeL SOM+ cells; the knockout raised the AMPA/NMDA ratio, left paired-pulse ratio unchanged and gave a non-significant amplitude trend.”
Status: proposed
Drafted and checked by AI models; it stays proposed until people have audited a sample of such claims.