clm-stb9y2j6gd

ORB (Orbital area) functionally connects to AI (Agranular insular area)

Species: Mouse
Result: present
Method: optogenetic circuit mapping
Sign: excitatory
Evidence: Stimulating orbitofrontal axons in insular slices produced excitatory currents in about two thirds of recorded amygdala-projecting insular neurons, with a higher inhibitory-to-excitatory ratio than in accumbens-projecting neurons.
Measurements: connection probability: 0.69, n = 16
Source: Insular cortical circuits as an executive gateway to decipher threat or extinction memory via distinct subcortical pathways
Nature Communications, 2022
DOI 10.1038/s41467-022-33241-9 · PubMed 36130959 · PMC9492683, Supplementary Fig. 23c–f
Licence: CC-BY-4.0
Named in the paper: “OFC” and “IC-CeA projectors”
Made by: an AI model reading the paper (claude-opus-5, extract@0.3.0), 2026-10-09
Checked by: a second AI model (claude-opus-5) agrees, 2026-10-09
“OFC terminal stimulation evoked EPSCs in 11/16 IC-CeA projectors with a higher IPSC/EPSC ratio.”
Status: proposed
Drafted and checked by AI models; it stays proposed until people have audited a sample of such claims.