clm-t09r7mgjxs

DR (Dorsal nucleus raphe) projects to PL (Prelimbic area)

Species: Rat
Result: present
Method: retrograde tracer
Sign: unknown
Evidence: Bilateral injection of retrograde AAV-CAG-tdTomato into medial prefrontal cortex labelled neurons in the dorsal raphe, clustered mainly in the interfascicular/ventromedial DRN, showing that DRN neurons project to mPFC. Most of these retrogradely labelled cells were Tph2-positive (serotonergic) and more than 73% were nNOS-positive.
Source: Chemogenetic inhibition of prefrontal cortex inputs to dorsal raphe reduces anxiety behaviors in male rat model of fetal alcohol spectrum disorder
Scientific Reports, 2025
DOI 10.1038/s41598-025-99181-8 · PubMed 40275074 · PMC12022358, Fig. 1A–D; Fig. 3A–C
Licence: CC-BY-NC-ND-4.0
Named in the paper: “DRN” and “mPFC”
Made by: an AI model reading the paper (claude-opus-5, extract@0.3.0), 2026-10-09
Checked by: a second AI model (claude-opus-5) agrees, 2026-10-09
“Retrograde labelling from mPFC identified Tph2+ ventromedial DRN neurons with >73% nNOS positivity.”
Status: proposed
Drafted and checked by AI models; it stays proposed until people have audited a sample of such claims.