clm-vja4dja43a

sAMY (Striatum-like amygdalar nuclei) functionally connects to PAG (Periaqueductal gray)

Species: Mouse
Result: present
Method: optogenetic circuit mapping
Sign: inhibitory
Evidence: In brain slices, optogenetic stimulation of ChR2-expressing GABAergic AmgC/M axons in the PAG evoked IPSCs in 16 of 29 CANE-tagged PAG-USV neurons recorded in TTX/4AP (mean ~180 pA at 0 mV); these currents reversed near the chloride equilibrium potential and were eliminated by gabazine, and no EPSCs were seen at -70 mV.
Measurements: connection probability: 0.552, n = 29
Source: Circuit and synaptic organization of forebrain-to-midbrain pathways that promote and suppress vocalization
eLife, 2020
DOI 10.7554/elife.63493 · PubMed 33372655 · PMC7793624, Fig. 5C–F
Licence: CC-BY-4.0
Named in the paper: “AmgC/M-PAG axons” and “PAG-USV neurons”
Made by: an AI model reading the paper (claude-opus-5, extract@0.3.0), 2026-10-10
Checked by: a second AI model (claude-opus-5-5) agrees, 2026-10-10
“16 of 29 PAG-USV cells showed gabazine-sensitive IPSCs in TTX/4AP, which matches 0.552.”
Status: proposed
Drafted and checked by AI models; it stays proposed until people have audited a sample of such claims.