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PL (Prelimbic area) functionally connects to PAG (Periaqueductal gray)

Species: Mouse
Result: present
Method: optogenetic circuit mapping
Sign: excitatory
Evidence: A single blue light pulse applied to ChR2-expressing PrL terminals in the lateral/ventrolateral PAG evoked an EPSC in PAG neurons; the response was blocked by TTX and recovered with 4-AP, consistent with a monosynaptic excitatory projection.
Source: Elevated prelimbic cortex-to-basolateral amygdala circuit activity mediates comorbid anxiety-like behaviors associated with chronic pain
Journal of Clinical Investigation, 2023
DOI 10.1172/jci166356 · PubMed 36917193 · PMC10145931, Supplemental Fig. 6B–D
Licence: CC-BY-4.0
Named in the paper: “PrL” and “l/vlPAG”
Made by: an AI model reading the paper (claude-opus-5, extract@0.3.0), 2026-10-09
Checked by: a second AI model (claude-opus-5) agrees, 2026-10-09
“Blue-light-evoked EPSCs in l/vlPAG neurons blocked by TTX and rescued by 4-AP indicate a monosynaptic excitatory PrL input.”
Status: proposed
Drafted and checked by AI models; it stays proposed until people have audited a sample of such claims.