clm-x33vxwa888

PL (Prelimbic area) projects to PAG (Periaqueductal gray)

Species: Mouse
Result: present
Method: anterograde tracer
Sign: unknown
Strength: strong
Evidence: After injecting an AAV expressing mCherry into the PrL, the authors saw extensive labelled axonal fibers in the lateral/ventrolateral PAG.
Source: Elevated prelimbic cortex-to-basolateral amygdala circuit activity mediates comorbid anxiety-like behaviors associated with chronic pain
Journal of Clinical Investigation, 2023
DOI 10.1172/jci166356 · PubMed 36917193 · PMC10145931, Supplemental Fig. 6A
Licence: CC-BY-4.0
Named in the paper: “PrL” and “l/vlPAG”
Made by: an AI model reading the paper (claude-opus-5, extract@0.3.0), 2026-10-09
Checked by: a second AI model (claude-opus-5) agrees, 2026-10-09
“mCherry-expressing AAV in PrL produced extensive fibers in l/vlPAG, consistent with a strong anterograde projection.”
Status: proposed
Drafted and checked by AI models; it stays proposed until people have audited a sample of such claims.