clm-xewvsq2879

PVH (Paraventricular hypothalamic nucleus) functionally connects to PL (Prelimbic area)

Species: Mouse
Result: present
Method: optogenetic circuit mapping
Sign: inhibitory
Evidence: Optogenetic inhibition of oxytocinergic PVN axon terminals in the prelimbic cortex raised the calcium transient rate of prefrontal excitatory neurons in acutely and chronically stressed mice (but not in unstressed mice), indicating a state-dependent suppressive action of PVN oxytocin input on prefrontal pyramidal activity.
Source: Medial prefrontal cortex neurons integrate amygdala and hypothalamic oxytocin signals to mediate stress-induced social alterations
Communications Biology, 2026
DOI 10.1038/s42003-026-10089-z · PubMed 42026195 · PMC13316100, Fig. 6c, d
Licence: CC-BY-NC-ND-4.0
Named in the paper: “PVN-mPFC OXT neurons” and “mPFC (PL) pyramidal neurons”
Made by: an AI model reading the paper (claude-opus-5, extract@0.3.0), 2026-10-09
Checked by: a second AI model (claude-opus-5) agrees, 2026-10-09
“Inhibiting PVN OXT terminals in PL raised pyramidal activity only in stressed mice, as stated for Fig. 6c, d.”
Status: proposed
Drafted and checked by AI models; it stays proposed until people have audited a sample of such claims.