Mouse

PVH (Paraventricular hypothalamic nucleus) functionally connects to PL (Prelimbic area)

1 claim from 1 source: 1 found, 0 tested and absent, 0 ambiguous. Evidence: optogenetic circuit mapping.

The claims behind it

clm-xewvsq2879presentoptogenetic circuit mappingproposed

Optogenetic inhibition of oxytocinergic PVN axon terminals in the prelimbic cortex raised the calcium transient rate of prefrontal excitatory neurons in acutely and chronically stressed mice (but not in unstressed mice), indicating a state-dependent suppressive action of PVN oxytocin input on prefrontal pyramidal activity.

DOI 10.1038/s42003-026-10089-z · PubMed 42026195 · PMC13316100, Fig. 6c, d

Made by an AI model reading the paper (claude-opus-5, extract@0.3.0); a second AI model (claude-opus-5) agrees.