clm-xr2pd327e2

AI (Agranular insular area) functionally connects to ACB (Nucleus accumbens)

Species: Mouse
Result: present
Method: optogenetic circuit mapping
Sign: excitatory
Evidence: Insular neurons labelled by the intersectional strategy as receiving orbitofrontal input and projecting to the accumbens produced excitatory postsynaptic currents in accumbens neurons when their terminals were photostimulated.
Source: Insular cortical circuits as an executive gateway to decipher threat or extinction memory via distinct subcortical pathways
Nature Communications, 2022
DOI 10.1038/s41467-022-33241-9 · PubMed 36130959 · PMC9492683, Supplementary Fig. 25
Licence: CC-BY-4.0
Named in the paper: “IC neurons in the OFC → IC → NAc pathway” and “NAc”
Made by: an AI model reading the paper (claude-opus-5, extract@0.3.0), 2026-10-09
Checked by: a second AI model (claude-opus-5) agrees, 2026-10-09
“Photostimulation of these labeled IC neurons' terminals evoked oEPSCs in NAc neurons.”
Status: proposed
Drafted and checked by AI models; it stays proposed until people have audited a sample of such claims.