clm-y813k6z9qj
ACA (Anterior cingulate area) functionally connects to Isocortex
All claims for this connection- Species
- Mouse
- Result
- present
- Method
- optogenetic circuit mapping
- Sign
- unknown
- Evidence
- Halorhodopsin silencing of ACC axon terminals in the vmPFC during observational fear changed vmPFC calcium activity. Freezing-negative neurons no longer showed increased activity at the demonstrator's shock, and shock-activated neurons lost their negative correlation with freezing. The authors conclude that this subpopulation's mixed selectivity depends on ACC input.
- Source
Ventromedial prefrontal neurons represent self-states shaped by vicarious fear in male mice
Nature Communications, 2023
DOI 10.1038/s41467-023-39081-5 · PubMed 37400435 · PMC10318047, Fig. 6a–h; Results, 'Physiological activity in the vmPFC during inhibition of the ACC-vmPFC and BLA-vmPFC pathways'Licence: CC-BY-4.0
- Named in the paper
- “ACC” and “vmPFC”
- Made by
- an AI model reading the paper (claude-opus-5-5, extract@0.3.0), 2026-10-09
- Checked by
a second AI model (claude-opus-5-5) agrees, 2026-10-09
“Fig. 6a–h shows that NpHR silencing of ACC terminals in the vmPFC abolished the shock-evoked increase in freezing-negative neurons and the negative freezing correlation of shock-activated neurons, in male mice.”
- Status
proposed
Drafted and checked by AI models; it stays proposed until people have audited a sample of such claims.