Mouse

ACA (Anterior cingulate area) functionally connects to Isocortex

1 claim from 1 source: 1 found, 0 tested and absent, 0 ambiguous. Evidence: optogenetic circuit mapping.

The claims behind it

clm-y813k6z9qjpresentoptogenetic circuit mappingproposed

Halorhodopsin silencing of ACC axon terminals in the vmPFC during observational fear changed vmPFC calcium activity. Freezing-negative neurons no longer showed increased activity at the demonstrator's shock, and shock-activated neurons lost their negative correlation with freezing. The authors conclude that this subpopulation's mixed selectivity depends on ACC input.

DOI 10.1038/s41467-023-39081-5 · PubMed 37400435 · PMC10318047, Fig. 6a–h; Results, 'Physiological activity in the vmPFC during inhibition of the ACC-vmPFC and BLA-vmPFC pathways'

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.