clm-y978wjtb0y

BLA (Basolateral amygdalar nucleus) functionally connects to BLA glutamatergic principal neurons

Species: Mouse
Result: present
Method: optogenetic circuit mapping
Sign: inhibitory
Evidence: Sequential patterned-light activation of individual soma-targeted ChR2-expressing neurons within the basal amygdala, with glutamate receptors blocked by NBQX and L-APV, evoked IPSCs in non-expressing BA principal neurons, demonstrating local inhibitory connections; connection probability and quantal IPSC amplitude were both lower in NRXN1alpha knockouts (about 69-71 presynaptic cells probed per recorded neuron).
Source: Deletion of NRXN1α impairs long-range and local connectivity in amygdala fear circuit
Translational Psychiatry, 2020
DOI 10.1038/s41398-020-00926-y · PubMed 32684634 · PMC7370229, Fig. 4a–f
Licence: CC-BY-4.0
Named in the paper: “BA (local GABAergic neurons)” and “BA principal neuron”
Made by: an AI model reading the paper (claude-opus-5, extract@0.3.0), 2026-10-09
Checked by: a second AI model (claude-opus-5) agrees, 2026-10-09
“Soma-targeted ChR2 mapping with glutamate blockers revealed local BA inhibitory inputs onto principal neurons, with the stated cell counts.”
Status: proposed
Drafted and checked by AI models; it stays proposed until people have audited a sample of such claims.