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PL (Prelimbic area) functionally connects to BLA glutamatergic principal neurons
All claims for this connection- Species
- Mouse
- Result
- present
- Method
- optogenetic circuit mapping
- Sign
- unknown
- Evidence
- About 85% of the Fos-positive nuclei driven in the medial basolateral amygdala by prefrontal D1 photostimulation were CaMKII-positive (roughly 20% of CaMKII cells in this territory). Silencing these CaMKII neurons with halorhodopsin and yellow light abolished the feeding increase produced by blue-light stimulation of the prefrontal D1 terminals, indicating that the prefrontal input acts through these amygdala glutamatergic cells.
- Source
Medial prefrontal D1 dopamine neurons control food intake
Nature Neuroscience, 2014
DOI 10.1038/nn.3625 · PubMed 24441680 · PMC3968853, Fig. 5d,f; Fig. 6g-i- Named in the paper
- “medial prefrontal cortex (mPFC)” and “CaMKII-positive mBLA neurons”
- Made by
- an AI model reading the paper (claude-opus-5, extract@0.3.0), 2026-10-09
- Checked by
a second AI model (claude-opus-5) agrees, 2026-10-09
“~85% of Fos cells were CaMKII-positive and silencing them blocked the feeding effect, supporting functional input to BLA glutamatergic neurons.”
- Status
proposed
Drafted and checked by AI models; it stays proposed until people have audited a sample of such claims.