Mouse

CL:0000700 functionally connects to ACB (Nucleus accumbens)

1 claim from 1 source: 1 found, 0 tested and absent, 0 ambiguous. Evidence: optogenetic circuit mapping.

The claims behind it

clm-r5z68wn8hypresentoptogenetic circuit mappingproposed

In DAT-Cre mice in which ChrimsonR was restricted to dopaminergic VTA neurons, red-light stimulation through an implanted LED array in the VTA raised extracellular dopamine measured by microdialysis/HPLC in the nucleus accumbens shell; the increase was larger at 20 Hz than at 2 Hz (paired t-test p = 0.000116 at 2 Hz and p = 0.00599 at 20 Hz for the 15-min sample immediately after stimulation). Immunostaining confirmed ChrimsonR/TH co-localization and c-fos induction in these neurons after stimulation.

DOI 10.3390/ijms23031114 · PubMed 35163036 · PMC8834722, Fig. 3(b-1,b-2); Results 2.3

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