clm-r5z68wn8hy

CL:0000700 functionally connects to ACB (Nucleus accumbens)

Species: Mouse
Result: present
Method: optogenetic circuit mapping
Sign: modulatory
Evidence: In DAT-Cre mice in which ChrimsonR was restricted to dopaminergic VTA neurons, red-light stimulation through an implanted LED array in the VTA raised extracellular dopamine measured by microdialysis/HPLC in the nucleus accumbens shell; the increase was larger at 20 Hz than at 2 Hz (paired t-test p = 0.000116 at 2 Hz and p = 0.00599 at 20 Hz for the 15-min sample immediately after stimulation). Immunostaining confirmed ChrimsonR/TH co-localization and c-fos induction in these neurons after stimulation.
Source: Investigating the Influence of GABA Neurons on Dopamine Neurons in the Ventral Tegmental Area Using Optogenetic Techniques
International Journal of Molecular Sciences, 2022
DOI 10.3390/ijms23031114 · PubMed 35163036 · PMC8834722, Fig. 3(b-1,b-2); Results 2.3
Licence: CC-BY-4.0
Named in the paper: “DA neurons in the VTA (DAT-Cre, ChrimsonR-expressing)” and “NAcShell (nucleus accumbens shell)”
Made by: an AI model reading the paper (claude-opus-5, extract@0.3.0), 2026-10-10
Checked by: a second AI model (claude-opus-5) agrees, 2026-10-10
“DAT-Cre DA-specific stimulation increased NAcShell dopamine with the stated p-values and frequency dependence, confirmed by TH/c-fos staining.”
Status: proposed
Drafted and checked by AI models; it stays proposed until people have audited a sample of such claims.