Mouse

MEA (Medial amygdalar nucleus) functionally connects to ARH (Arcuate hypothalamic nucleus)

2 claims from 1 source: 1 found, 1 tested and absent, 0 ambiguous. Evidence: optogenetic circuit mapping.

The claims behind it

clm-a6jp4vtb3dpresentoptogenetic circuit mappingproposed

Selective 10 Hz activation of MePD UCN3 neurons that do not express GABA increased the LH inter-pulse interval (15.47 ± 0.91 min before versus 23.75 ± 1.07 min during stimulation, n = 6), with no change in no-stimulation or control-virus groups; the same stimulation combined with optogenetic silencing of non-UCN3 MePD GABA neurons no longer altered LH pulse interval, indicating the effect on the pulse generator requires MePD GABA neurons.

DOI 10.1038/s41467-026-70364-9 · PubMed 41807404 · PMC13319269, Fig. 5A–D; Fig. 6H–J

Made by an AI model reading the paper (claude-opus-5, extract@0.3.0); a second AI model (claude-opus-5) agrees.

clm-bzj4530nhxabsentoptogenetic circuit mappingproposed

Selective 10 Hz activation of MePD neurons co-expressing UCN3 and GABA did not change the LH inter-pulse interval compared with the control period (n = 6), and the matched no-stimulation cohort also showed no change, so this subpopulation alone did not influence the GnRH pulse generator output.

DOI 10.1038/s41467-026-70364-9 · PubMed 41807404 · PMC13319269, Fig. 5H–J

Made by an AI model reading the paper (claude-opus-5, extract@0.3.0); a second AI model (claude-opus-5) agrees.