Skip to content

Mouse

PIL (Posterior intralaminar thalamic nucleus) functionally connects to Intercalated cell GABAergic neurons

2 claims from 1 source: 2 found, 0 tested and absent, 0 ambiguous. Evidence: optogenetic circuit mapping.

The claims behind it

clm-bk5853g2tqpresentoptogenetic circuit mappingproposed

Blue-light activation of ChR2-expressing thalamic terminals evoked glutamatergic EPSCs in patched medial paracapsular intercalated cells, with AMPA receptor-mediated currents isolated at -70 mV in bicuculline and NMDA receptor-mediated currents isolated with NBQX; responses were graded with light intensity in both genotypes.

DOI 10.3389/fnsyn.2021.697110 · PubMed 34393751 · PMC8355744, Fig. 2D,E; Fig. 3A,D,E

Made by an AI model reading the paper (claude-opus-5, extract@0.3.0); a second AI model (claude-opus-5) agrees.

clm-s05ppmkyc1presentoptogenetic circuit mappingproposed

Optogenetic stimulation of thalamic terminals also elicited excitation-driven GABAergic IPSCs recorded at 0 mV in medial paracapsular intercalated cells; these inhibitory responses were larger in ErbB4 conditional knockouts, lowering the excitation/inhibition ratio.

DOI 10.3389/fnsyn.2021.697110 · PubMed 34393751 · PMC8355744, Fig. 2D,F,G

Made by an AI model reading the paper (claude-opus-5, extract@0.3.0); a second AI model (claude-opus-5) agrees.