P (Pons) projects to MY (Medulla)

After AAV-driven overexpression of human alpha-synuclein restricted to medullary neurons (vagus nerve injection), immunoreactive axons appeared in the pons by 8 weeks and increased markedly by 18 weeks, both ipsilateral and, at roughly a third of the ipsilateral count, contralateral to the injection; the authors attribute this to transfer of the protein into fibres of pontine neurons that innervate the medulla.

Made by an AI model reading the paper (claude-opus-5, extract@0.3.0); a second AI model (claude-opus-5) agrees.