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Rat

PB (Parabrachial nucleus) functionally connects to CEA (central amygdaloid nucleus)

1 claim from 1 source: 1 found, 0 tested and absent, 0 ambiguous. Evidence: optogenetic circuit mapping.

The claims behind it

clm-yw13gev11xpresentoptogenetic circuit mappingproposed

Yellow-light silencing of NpHR-expressing PBN axon terminals in the right CeA lowered the number of c-Fos-positive CeA neurons and reduced pain hypersensitivity and anxiety-like behaviour in paclitaxel-treated rats, while blue-light activation of ChR2-expressing PBN terminals in the CeA of naive rats produced hypersensitivity and anxiety-like behaviour; a week of daily terminal inhibition also lowered CeA PDYN mRNA.

DOI 10.1002/cns.71065 · PubMed 42656049 · PMC13519527, Fig. 3C–K; Fig. 4C–K; Fig. 5A–C, F

Made by an AI model reading the paper (claude-opus-5, extract@0.3.0); not checked yet.