clm-yw13gev11x
PB (Parabrachial nucleus) functionally connects to CEA (central amygdaloid nucleus)
All claims for this connection- Species
- Rat
- Result
- present
- Method
- optogenetic circuit mapping
- Sign
- unknown
- Evidence
- Yellow-light silencing of NpHR-expressing PBN axon terminals in the right CeA lowered the number of c-Fos-positive CeA neurons and reduced pain hypersensitivity and anxiety-like behaviour in paclitaxel-treated rats, while blue-light activation of ChR2-expressing PBN terminals in the CeA of naive rats produced hypersensitivity and anxiety-like behaviour; a week of daily terminal inhibition also lowered CeA PDYN mRNA.
- Source
Role of PBN ‐ CeA Circuit in Paclitaxel‐Induced Neuropathic Pain and Negative Emotions
CNS Neuroscience & Therapeutics, 2026
DOI 10.1002/cns.71065 · PubMed 42656049 · PMC13519527, Fig. 3C–K; Fig. 4C–K; Fig. 5A–C, FLicence: CC-BY-4.0
- Named in the paper
- “PBN” and “CeA”
- Made by
- an AI model reading the paper (claude-opus-5, extract@0.3.0), 2026-10-09
- Status
proposed
Drafted and checked by AI models; it stays proposed until people have audited a sample of such claims.