PL (Prelimbic area) functionally connects to Rat basal amygdaloid nucleus principal neurons

Blue-light activation of ChR2-expressing dorsal mPFC fibres near the stria terminalis evoked EPSCs in BLA principal neurons; these were abolished by TTX and restored by 4-AP (indicating monosynaptic transmission) and blocked by the AMPA antagonist DNQX, establishing a glutamatergic connection.

Made by an AI model reading the paper (claude-opus-5, extract@0.3.0); a second AI model (claude-opus-5) agrees.

Light activation of dorsal mPFC terminals also evoked GABAergic IPSCs in BLA principal neurons recorded at 0 mV; their onset was much later than the EPSCs and they were blocked by picrotoxin as well as by DNQX, indicating a polysynaptic local inhibitory circuit recruited by this input.

Made by an AI model reading the paper (claude-opus-5, extract@0.3.0); a second AI model (claude-opus-5) disagrees. “The dmPFC-evoked IPSCs are blocked by DNQX, indicating a polysynaptic feedback circuit rather than an inhibitory dmPFC connection.”