Mouse

BLA VIP-expressing interneurons functionally connects to BLA glutamatergic principal neurons

1 claim from 1 source: 1 found, 0 tested and absent, 0 ambiguous. Evidence: optogenetic circuit mapping.

The claims behind it

clm-7wedvkp8p2presentoptogenetic circuit mappingproposed

In VIP-IRES-cre::Ai32 slices, blue-light activation of ChR2-expressing VIP+ interneurons evoked CNQX-resistant IPSPs in about one-fifth of recorded BLA principal neurons; these were abolished by the CB1 agonist WIN 55,212-2 and rescued by AM251, pointing to VIP+/CB1+ basket cells. Light-evoked inhibitory responses were also seen in EGFP+ principal neurons in VIP-cre::GAD65-EGFP mice.

DOI 10.1523/jneurosci.2063-17.2018 · PubMed 29954847 · PMC6070667, Fig. 7A–F; Fig. 8D–F

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