clm-7wedvkp8p2
BLA VIP-expressing interneurons functionally connects to BLA glutamatergic principal neurons
All claims for this connection- Species
- Mouse
- Result
- present
- Method
- optogenetic circuit mapping
- Sign
- inhibitory
- Evidence
- In VIP-IRES-cre::Ai32 slices, blue-light activation of ChR2-expressing VIP+ interneurons evoked CNQX-resistant IPSPs in about one-fifth of recorded BLA principal neurons; these were abolished by the CB1 agonist WIN 55,212-2 and rescued by AM251, pointing to VIP+/CB1+ basket cells. Light-evoked inhibitory responses were also seen in EGFP+ principal neurons in VIP-cre::GAD65-EGFP mice.
- Measurements
- connection probability: 0.2, n = 78
- Source
The Journal of Neuroscience, 2018
DOI 10.1523/jneurosci.2063-17.2018 · PubMed 29954847 · PMC6070667, Fig. 7A–F; Fig. 8D–F- Named in the paper
- “VIP+ INs (VIP+ basket cells, CCK+/CB1+/VIP+)” and “principal neurons”
- Made by
- an AI model reading the paper (claude-opus-5-5, extract@0.3.0), 2026-10-10
- Checked by
a second AI model (claude-opus-5-5) agrees, 2026-10-10
“Fig. 7 shows light-evoked, CNQX-resistant, CB1-sensitive IPSPs in about 20% of 78 principal neurons, and Fig. 8F reports inhibitory responses in EGFP+ principal neurons.”
- Status
proposed
Drafted and checked by AI models; it stays proposed until people have audited a sample of such claims.