Role of PBN ‐ CeA Circuit in Paclitaxel‐Induced Neuropathic Pain and Negative Emotions

PB (Parabrachial nucleus) UBERON:0007634 projects to CEA (central amygdaloid nucleus) UBERON:0002883 · Rat

After injecting an mCherry-expressing AAV into the right parabrachial nucleus, labelled cell bodies were seen in the right PBN and labelled axon terminals were found in the right central amygdala, which the authors interpreted as a direct PBN-to-CeA projection.

Fig. 3A–B; Fig. 5E

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PB (Parabrachial nucleus) UBERON:0007634 functionally connects to CEA (central amygdaloid nucleus) UBERON:0002883 · Rat

Yellow-light silencing of NpHR-expressing PBN axon terminals in the right CeA lowered the number of c-Fos-positive CeA neurons and reduced pain hypersensitivity and anxiety-like behaviour in paclitaxel-treated rats, while blue-light activation of ChR2-expressing PBN terminals in the CeA of naive rats produced hypersensitivity and anxiety-like behaviour; a week of daily terminal inhibition also lowered CeA PDYN mRNA.

Fig. 3C–K; Fig. 4C–K; Fig. 5A–C, F

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