Selective inhibitory control of pyramidal neuron ensembles and cortical subnetworks by chandelier cells

PL (Prelimbic area) MBA:972 projects to CP (Caudoputamen) MBA:672 · Mouse

A third CTB color injected into dorsomedial striatum labelled PL upper-layer pyramidal cells at a characteristic depth.

Fig. 1c-d

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

VTA (Ventral tegmental area) MBA:749 synapses onto PL (Prelimbic area) MBA:972 · Mouse

The VTA is listed among sources of rabies-labelled presynaptic neurons to PL ChCs.

Fig. 4g

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

PAG (Periaqueductal gray) MBA:795 synapses onto PL (Prelimbic area) MBA:972 · Mouse

The periaqueductal gray is listed as a source of rabies-labelled input to PL ChCs.

Fig. 4g

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

BLA (Basolateral amygdalar nucleus) MBA:295 functionally connects to PL (Prelimbic area) MBA:972 · Mouse

Optogenetic activation of ChR2-expressing BLA axons in PL evoked only weak responses in ChCs relative to neighbouring pyramidal cells (charge ratio about 0.35).

Fig. 4h-i

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

HIP (Hippocampal region) MBA:1080 synapses onto PL (Prelimbic area) MBA:972 · Mouse

Ventral hippocampus contributed rabies-labelled presynaptic neurons to PL ChCs in the long-range input distribution.

Fig. 4g

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

MD (Mediodorsal nucleus of thalamus) MBA:362 synapses onto PL (Prelimbic area) MBA:972 · Mouse

Rabies tracing from ChCs labelled presynaptic neurons in mediodorsal thalamus as a major long-range input.

Fig. 4f-g

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

ORB (Orbital area) MBA:714 synapses onto PL (Prelimbic area) MBA:972 · Mouse

Orbitofrontal cortex is shown as a source of rabies-labelled input to PL ChCs.

Fig. 4g

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

GPi (Globus pallidus, internal segment) MBA:1031 synapses onto PL (Prelimbic area) MBA:972 · Mouse

The internal globus pallidus is shown as a source of rabies-labelled input to PL ChCs.

Fig. 4g

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

NDB (Diagonal band nucleus) MBA:596 synapses onto PL (Prelimbic area) MBA:972 · Mouse

Monosynaptic rabies tracing from PL L2 ChCs labelled many presynaptic neurons in the diagonal band, including cholinergic cells; this was the largest long-range source.

Fig. 4f-g

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

AM (Anteromedial nucleus) MBA:127 synapses onto PL (Prelimbic area) MBA:972 · Mouse

Anteromedial thalamus contained a substantial share of rabies-labelled presynaptic neurons to PL ChCs.

Fig. 4f-g

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

BLA (Basolateral amygdalar nucleus) MBA:295 synapses onto PL (Prelimbic area) MBA:972 · Mouse

Only a small fraction of rabies-labelled long-range inputs to PL ChCs were in the basolateral amygdala, making it a minor source.

Fig. 4f-g

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

RSPd (Retrosplenial area, dorsal part) MBA:879 synapses onto PL (Prelimbic area) MBA:972 · Mouse

Dorsal retrosplenial cortex is listed as a source of rabies-labelled presynaptic neurons to PL ChCs.

Fig. 4g

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

MO (Somatomotor areas) MBA:500 synapses onto PL (Prelimbic area) MBA:972 · Mouse

Motor cortex appears among the sources of rabies-labelled long-range input to PL ChCs in the brain-wide distribution.

Fig. 4g

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

PIR (Piriform area) MBA:961 synapses onto PL (Prelimbic area) MBA:972 · Mouse

Piriform cortex is listed among long-range sources of rabies-labelled presynaptic cells to PL ChCs.

Fig. 4g

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

VM (Ventral medial nucleus of the thalamus) MBA:685 synapses onto PL (Prelimbic area) MBA:972 · Mouse

Ventromedial thalamus was among the main long-range sources of rabies-labelled input to PL ChCs.

Fig. 4f-g

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

PL (Prelimbic area) MBA:972 projects to BLA (Basolateral amygdalar nucleus) MBA:295 · Mouse

CTB injected into the basolateral amygdala retrogradely labelled a subset of superficial-layer pyramidal cells in prelimbic cortex, located at a depth similar to L2 chandelier cells.

Fig. 1c-e

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

PL (Prelimbic area) MBA:972 functionally connects to BLA (Basolateral amygdalar nucleus) MBA:295 · Mouse

Optogenetic activation of PL ChCs produced a positive-going evoked potential in the ipsilateral BLA LFP 5-10 ms after light onset, interpreted as reduced PL-to-BLA drive.

Fig. 5h

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.