Fluoxetine-induced recovery of serotonin and norepinephrine projections in a mouse model of post-stroke depression

CL:0000850 projects to ACA (Anterior cingulate area) MBA:31 · Mouse

In Pet-Cre x Ai32 mice, where ChR2-YFP is expressed only in serotonergic neurons, YFP-labelled axons that largely overlapped with SERT staining were seen in the cingulate gyrus of sham control mice. This labelling dropped after a left mPFC stroke and recovered with chronic fluoxetine.

Fig. 2a; Results, Pet-ChR2 section

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

CL:0000850 projects to BLA (Basolateral amygdalar nucleus) MBA:295 · Mouse

In mice expressing ChR2-YFP selectively in serotonergic neurons, YFP-positive axons that colocalized with SERT were present in the basolateral amygdala of sham mice. The left BLA showed reduced labelling after mPFC stroke, and the labelling was restored by chronic fluoxetine.

Fig. 2b; Results, Pet-ChR2 section

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.