Social incentivization of instrumental choice in mice requires amygdala-prelimbic cortex-nucleus accumbens connectivity

PL (Prelimbic area) MBA:972 projects to ACB (Nucleus accumbens) MBA:56 · Mouse

Retrograde AAV expressing Cre-GFP was injected into the nucleus accumbens with a Cre-dependent Gi-DREADD-mCherry vector in prelimbic cortex; co-labelled Cre+/mCherry+ neurons in PL demonstrate a prelimbic projection to the accumbens.

Fig. 5e (right panel); Methods, Table 2

Made by an AI model reading the paper (claude-opus-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

BLA (Basolateral amygdalar nucleus) MBA:295 projects to PL (Prelimbic area) MBA:972 · Mouse

A retrogradely transported AAV carrying Cre-GFP was placed in the prelimbic cortex together with a Cre-dependent Gi-DREADD-mCherry vector in the basolateral amygdala; mCherry-labelled amygdala cells confirmed that BLA neurons send axons to PL, and these cells could be chemogenetically silenced (verified by patch-clamp in Fig. S3).

Fig. 5e (left panel); Methods, Table 2

Made by an AI model reading the paper (claude-opus-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.