Experience-dependent plasticity in an innate social behavior is mediated by hypothalamic LTP

PA (Posterior amygdalar nucleus) MBA:780 functionally connects to VMH (Ventromedial hypothalamic nucleus) MBA:693 · Mouse

Photostimulation of Chronos-expressing AHiPM terminals in acute slices reliably evoked postsynaptic currents in tdTomato-identified Esr1 neurons of VMHvl when held at the reversal potential for inhibition (-70 mV), with no response detectable at the reversal potential for excitation (0 mV), indicating a purely excitatory and at least partly monosynaptic input; AMPA/NMDA ratios, synaptic integration, and ex vivo and in vivo (fEPSP) LTP/LTD were measured at this input.

Fig. 2 I–M; SI Appendix Fig. S2; Fig. 4 B–G, L, M, O

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PA (Posterior amygdalar nucleus) MBA:780 projects to VMH (Ventromedial hypothalamic nucleus) MBA:693 · Mouse

After viral expression of Chronos-eYFP restricted to AHiPM, labelled axonal processes originating from AHiPM were visualized in the ventrolateral VMH, and eYFP-positive terminals were seen in VMHvl near the implanted optic fiber/probe tract.

Fig. 2I (confocal image), Fig. 4J, Fig. 5A

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