clm-e25t4mv2cp

PA (Posterior amygdalar nucleus) functionally connects to VMH (Ventromedial hypothalamic nucleus)

Species: Mouse
Result: present
Method: optogenetic circuit mapping
Sign: excitatory
Strength: strong
Evidence: Photostimulation of Chronos-expressing AHiPM terminals in acute slices reliably evoked postsynaptic currents in tdTomato-identified Esr1 neurons of VMHvl when held at the reversal potential for inhibition (-70 mV), with no response detectable at the reversal potential for excitation (0 mV), indicating a purely excitatory and at least partly monosynaptic input; AMPA/NMDA ratios, synaptic integration, and ex vivo and in vivo (fEPSP) LTP/LTD were measured at this input.
Source: Experience-dependent plasticity in an innate social behavior is mediated by hypothalamic LTP
Proceedings of the National Academy of Sciences, 2020
DOI 10.1073/pnas.2011782117 · PubMed 32973099 · PMC7568289, Fig. 2 I–M; SI Appendix Fig. S2; Fig. 4 B–G, L, M, O
Licence: CC-BY-NC-ND-4.0
Named in the paper: “AHiPM” and “VMHvlEsr1 neurons”
Made by: an AI model reading the paper (claude-opus-5, extract@0.3.0), 2026-10-09
Checked by: a second AI model (claude-opus-5) agrees, 2026-10-09
“The paper's slice optogenetics establishes a purely excitatory, at least partly monosynaptic AHiPM input to VMHvl Esr1 neurons in mice, as described by the cited figures.”
Status: proposed
Drafted and checked by AI models; it stays proposed until people have audited a sample of such claims.