Amygdala-prefrontal pathways and the dopamine system affect nociceptive responses in the prefrontal cortex

BLA (basal amygdaloid nucleus) UBERON:0002887 functionally connects to Isocortex UBERON:0001950 · Rat

In urethane-anesthetized rats, high-frequency electrical stimulation of the BLA produced a long-lasting suppression, beginning within 10 min and lasting over 60 min, of tail-pressure-evoked nociceptive unit responses recorded in cingulate and prelimbic mPFC (9 units in 9 rats). This suppression was prevented by NMDA and group II mGluR antagonists and by D2 or D4 antagonists injected into the PFC.

Fig. 2A-C; Results, 'HFS delivered to the BLA modified pain responses recorded in the PFC'; Fig. 6

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