Synaptic Maturation at Cortical Projections to the Lateral Amygdala in a Mouse Model of Rett Syndrome

TH (Thalamus) MBA:549 functionally connects to LA glutamatergic principal neurons nt-659aayyts5 · Mouse

Stimulating thalamic afferents in the internal capsule evoked monosynaptic EPSCs in LA principal neurons, with phasic release properties that stayed largely constant from juvenile to adult ages. In adult mice these afferents also recruited strong picrotoxin-sensitive feed-forward IPSCs in the principal cells.

Fig. 1B, Fig. 2C, Fig. 4C-D; Results

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CTX (Cerebral cortex) MBA:688 functionally connects to LA glutamatergic principal neurons nt-659aayyts5 · Mouse

In acute coronal slices, stimulating cortical afferents in the external capsule evoked monosynaptic EPSCs with AMPA and NMDA components in patched LA principal neurons, in both juvenile and adult mice. The same stimulation also produced picrotoxin-sensitive feed-forward IPSCs. The paper tracked how paired-pulse ratio, refilling rate and maximal EPSC changed with age, and tested associative LTP at these synapses.

Fig. 1A, Fig. 2, Fig. 3, Fig. 4; Results

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