The delayed strengthening of synaptic connectivity in the amygdala depends on NMDA receptor activation during acute stress

TH (Thalamus) UBERON:0001897 functionally connects to Rat basal amygdaloid nucleus principal neurons nt-gv1k4bnh04 · Rat

Electrical stimulation of thalamic afferent fibers in amygdala slices evoked monosynaptic EPSCs in BLA principal neurons; the NMDA receptor component was isolated with CNQX and picrotoxin at +40 mV and progressively blocked by MK-801 during repeated stimulation, with a faster decay constant in slices from stressed rats (control 33.47 ± 2.3, n = 12; stress 25.03 ± 2.03, n = 12), indicating higher presynaptic release probability at this thalamic input ten days after acute stress.

Materials and Methods (electrophysiology); Fig. 2A–C

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