Whole-Brain Mapping of Direct Inputs to Dopamine D1 and D2 Receptor-Expressing Medium Spiny Neurons in the Posterior Dorsomedial Striatum

CEA (Central amygdalar nucleus) MBA:536 synapses onto CP (Caudoputamen) MBA:672 · Mouse

CeA neurons were labeled as monosynaptic inputs to pDMS D2-MSNs.

Fig. 1Dxii, 2

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

MOp (Primary motor area) MBA:985 synapses onto CP (Caudoputamen) MBA:672 · Mouse

Primary motor cortex provided a significantly larger share of inputs to pDMS D2-MSNs than to D1-MSNs.

Fig. 1D, 2

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

BLA (Basolateral amygdalar nucleus) MBA:295 synapses onto CP (Caudoputamen) MBA:672 · Mouse

Basal/basolateral amygdala neurons were rabies-labeled as inputs to pDMS D1-MSNs, with no bias between MSN types.

Fig. 1Dv, 2, 5B

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

PF (Parafascicular nucleus) MBA:930 synapses onto CP (Caudoputamen) MBA:672 · Mouse

The parafascicular thalamic nucleus was among the main thalamic sources of input to pDMS D2-MSNs.

Fig. 1D, 2

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

BST (Bed nuclei of the stria terminalis) MBA:351 synapses onto CP (Caudoputamen) MBA:672 · Mouse

BNST neurons were labeled as monosynaptic inputs to pDMS D2-MSNs. D2R-expressing BNST inputs were more common than D1R-expressing ones.

Fig. 1Dx, 4G

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

CEA (Central amygdalar nucleus) MBA:536 synapses onto CP (Caudoputamen) MBA:672 · Mouse

CeA neurons were rabies-labeled as inputs to pDMS D1-MSNs, in proportions similar to those for D2-MSNs.

Fig. 1Dv, 2

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

GPe (Globus pallidus, external segment) MBA:1022 synapses onto CP (Caudoputamen) MBA:672 · Mouse

GPe neurons were rabies-labeled as inputs to pDMS D1-MSNs, at a lower proportion than to D2-MSNs.

Fig. 1Div, 2

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

SNc (Substantia nigra, compact part) MBA:374 synapses onto CP (Caudoputamen) MBA:672 · Mouse

SNc neurons were labeled as monosynaptic inputs to pDMS D2-MSNs. D2R-expressing SNc inputs were enriched among them.

Fig. 1Dxiv, 2, 4G

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

TH (Thalamus) MBA:549 synapses onto CP (Caudoputamen) MBA:672 · Mouse

Thalamic neurons were labeled by rabies from pDMS D2-MSNs. The thalamus innervated D2-MSNs preferentially compared with D1-MSNs.

Fig. 1D, 1F

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

VIS (Visual areas) MBA:669 synapses onto CP (Caudoputamen) MBA:672 · Mouse

Secondary visual cortex was a smaller source of monosynaptic input to pDMS D2-MSNs than to D1-MSNs.

Fig. 2

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

MD (Mediodorsal nucleus of thalamus) MBA:362 synapses onto CP (Caudoputamen) MBA:672 · Mouse

Mediodorsal thalamus neurons were labeled as inputs to pDMS D2-MSNs. D2R-expressing MD neurons were enriched among them.

Fig. 2, 5C

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

ACA (Anterior cingulate area) MBA:31 synapses onto CP (Caudoputamen) MBA:672 · Mouse

Cingulate cortex neurons were labeled as monosynaptic inputs to pDMS D2-MSNs.

Fig. 1D, 2

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

MD (Mediodorsal nucleus of thalamus) MBA:362 synapses onto CP (Caudoputamen) MBA:672 · Mouse

Mediodorsal thalamus neurons were rabies-labeled as inputs to pDMS D1-MSNs.

Fig. 2

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

IMD (Intermediodorsal nucleus of the thalamus) MBA:59 synapses onto CP (Caudoputamen) MBA:672 · Mouse

Intermediodorsal thalamic nucleus contributed rabies-labeled inputs to pDMS MSNs. There was no difference among connection types.

Fig. 5C

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

GPe (Globus pallidus, external segment) MBA:1022 synapses onto CP (Caudoputamen) MBA:672 · Mouse

GPe provided significantly greater monosynaptic input to pDMS D2-MSNs than to D1-MSNs.

Fig. 1Dxi, 2

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

SNc (Substantia nigra, compact part) MBA:374 synapses onto CP (Caudoputamen) MBA:672 · Mouse

SNc provided a relatively small share of rabies-labeled inputs to pDMS D1-MSNs, not different from its share for D2-MSNs.

Fig. 1Dvii, 2

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

PVT (Paraventricular nucleus of the thalamus) MBA:149 synapses onto CP (Caudoputamen) MBA:672 · Mouse

PVT was among the thalamic nuclei providing rabies-labeled inputs to pDMS MSNs. Connection-type proportions did not differ.

Fig. 5C

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

BLA (Basolateral amygdalar nucleus) MBA:295 synapses onto CP (Caudoputamen) MBA:672 · Mouse

Basal/basolateral amygdala neurons were labeled as monosynaptic inputs to pDMS D2-MSNs.

Fig. 1Dxii, 2, 5B

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

VM (Ventral medial nucleus of the thalamus) MBA:685 synapses onto CP (Caudoputamen) MBA:672 · Mouse

The ventromedial thalamic nucleus preferentially provided monosynaptic input to pDMS D2-MSNs over D1-MSNs.

Fig. 2

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

ORB (Orbital area) MBA:714 synapses onto CP (Caudoputamen) MBA:672 · Mouse

Orbitofrontal cortex neurons were labeled as monosynaptic inputs to pDMS D2-MSNs.

Fig. 2; Results

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

LH (Lateral habenula) MBA:186 synapses onto CP (Caudoputamen) MBA:672 · Mouse

Lateral habenula neurons were included as rabies-labeled inputs onto pDMS D2-MSNs in the analysis of D1R- and D2R-expressing afferents.

Fig. 4G

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

AV (Anteroventral nucleus of thalamus) MBA:255 synapses onto CP (Caudoputamen) MBA:672 · Mouse

Anteroventral thalamic neurons were labeled as monosynaptic inputs to pDMS MSNs, including D2-MSNs.

Fig. 1Dxiii, 5C

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

CTX (Cerebral cortex) MBA:688 synapses onto CP (Caudoputamen) MBA:672 · Mouse

Rabies tracing from pDMS D2-MSNs labeled many cortical neurons. The cortex was the largest input source, though proportionally smaller than for D1-MSNs.

Fig. 1D, 1F

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

LA (Lateral amygdalar nucleus) MBA:131 synapses onto CP (Caudoputamen) MBA:672 · Mouse

Lateral amygdala neurons were labeled as monosynaptic inputs to pDMS D2-MSNs.

Fig. 2

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

CM (Central medial nucleus of the thalamus) MBA:599 synapses onto CP (Caudoputamen) MBA:672 · Mouse

The central thalamic nucleus provided a significantly higher proportion of inputs to pDMS D2-MSNs than to D1-MSNs.

Fig. 2

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

SSp (Primary somatosensory area) MBA:322 synapses onto CP (Caudoputamen) MBA:672 · Mouse

Primary sensory cortex provided a significantly greater proportion of inputs to pDMS D2-MSNs than to D1-MSNs.

Fig. 1D, 2

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

MOs (Secondary motor area) MBA:993 synapses onto CP (Caudoputamen) MBA:672 · Mouse

Secondary motor cortex neurons were labeled as monosynaptic inputs to pDMS D2-MSNs.

Fig. 1D, 2

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

PO (Posterior complex of the thalamus) MBA:1020 synapses onto CP (Caudoputamen) MBA:672 · Mouse

Posterior thalamic nucleus was among the thalamic regions providing rabies-labeled inputs to pDMS MSNs analyzed by receptor type.

Fig. 5C

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

BST (Bed nuclei of the stria terminalis) MBA:351 synapses onto CP (Caudoputamen) MBA:672 · Mouse

mCherry-positive rabies-labeled neurons presynaptic to pDMS D1-MSNs were found in the BNST.

Fig. 1Diii

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.