Vasoactive Intestinal Polypeptide-Immunoreactive Interneurons within Circuits of the Mouse Basolateral Amygdala

BLA VIP-expressing interneurons nt-8j60sp2qe4 functionally connects to BLA glutamatergic principal neurons nt-wprma5fcrr · Mouse

In VIP-IRES-cre::Ai32 slices, blue-light activation of ChR2-expressing VIP+ interneurons evoked CNQX-resistant IPSPs in about one-fifth of recorded BLA principal neurons; these were abolished by the CB1 agonist WIN 55,212-2 and rescued by AM251, pointing to VIP+/CB1+ basket cells. Light-evoked inhibitory responses were also seen in EGFP+ principal neurons in VIP-cre::GAD65-EGFP mice.

Fig. 7A–F; Fig. 8D–F

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

BLA VIP-expressing interneurons nt-8j60sp2qe4 functionally connects to BLA cholecystokinin-expressing interneurons nt-6730a6m5pa · Mouse

Light stimulation of ChR2-expressing VIP+ interneurons in VIP-cre::GAD65-EGFP mice evoked postsynaptic currents in EGFP+ CCK+ basket cells of the BLA. Gabazine abolished these responses, showing they were GABAA receptor-mediated.

Fig. 8D–F

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

BLA VIP-expressing interneurons nt-8j60sp2qe4 functionally connects to BLA neurogliaform cells nt-v3bbhjmhj0 · Mouse

Optogenetic activation of VIP+ interneurons evoked inhibitory postsynaptic responses in EGFP+ neurogliaform cells of the BLA. The authors conclude these responses are GABAA receptor-mediated.

Fig. 8D–F

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.