Activation of basolateral amygdala to anterior cingulate cortex circuit alleviates MK-801 induced social and cognitive deficits of schizophrenia

BLA glutamatergic principal neurons nt-wprma5fcrr projects to ACA (Anterior cingulate area) MBA:31 · Mouse

A retrograde AAV-Cre-mCherry injected into the ACC of GAD67-GFP mice labelled BLA cell bodies. These cells did not overlap with GAD67-GFP neurons and co-expressed Vglut2 mRNA, so the BLA-to-ACC projection neurons are glutamatergic.

Fig. 3C-E

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

BLA (Basolateral amygdalar nucleus) MBA:295 projects to ACA (Anterior cingulate area) MBA:31 · Mouse

After an AAV-hSyn-EGFP injection into the BLA of C57BL/6J mice, many labelled axon terminals were found in the ACC.

Fig. 3A-B

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

BLA (Basolateral amygdalar nucleus) MBA:295 functionally connects to ACA (Anterior cingulate area) MBA:31 · Mouse

In mice expressing ChR2 in the BLA, 20 Hz blue light delivered to BLA terminals in the ACC raised c-Fos expression in the ACC relative to mCherry controls. Yellow-light NpHR inhibition tended to have the opposite effect.

Fig. 5A-C

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.