Comparison of the connectivity of the posterior intralaminar thalamic nucleus and peripeduncular nucleus in rats and mice

PP (Peripeduncular nucleus) UBERON:0002144 projects to AAA (anterior amygdaloid area) UBERON:0002890 · Rat

Stronger PP terminal labelling was noted in the anterior amygdaloid area.

Fig. 5F

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PILN (posterior group of intralaminar nuclei) UBERON:0019295 projects to BLA (basal amygdaloid nucleus) UBERON:0002887 · Rat

No BDA terminal labelling from the PIL was detected in the basolateral nucleus.

Fig. 4E,F

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PILN (posterior group of intralaminar nuclei) UBERON:0019295 projects to CEA (central amygdaloid nucleus) UBERON:0002883 · Rat

Strong BDA terminal labelling from the PIL was found in the medial central amygdala.

Fig. 4D-F

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NLL (Nucleus of the lateral lemniscus) UBERON:0006840 projects to PP (Peripeduncular nucleus) UBERON:0002144 · Rat

A moderate number of neurons in the ventral nucleus of the lateral lemniscus were labelled from the PP.

Fig. 10L

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PBG (Parabigeminal nucleus) UBERON:0002140 projects to PP (Peripeduncular nucleus) UBERON:0002144 · Rat

Both BDA and FG injections in the PP retrogradely labelled many neurons in the parabigeminal nucleus.

Fig. 5H; Fig. 10F

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MT (Medial terminal nucleus of the accessory optic tract) UBERON:0013601 projects to PILN (posterior group of intralaminar nuclei) UBERON:0019295 · Rat

Medial terminal nucleus neurons were retrogradely labelled from the PIL.

Fig. 9J

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CUN (Cuneiform nucleus) UBERON:0002696 projects to PILN (posterior group of intralaminar nuclei) UBERON:0019295 · Rat

Contralateral cuneiform nucleus neurons were labelled by FG in the PIL.

Results, afferent projections (data not shown)

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NLL (Nucleus of the lateral lemniscus) UBERON:0006840 projects to PILN (posterior group of intralaminar nuclei) UBERON:0019295 · Rat

Neurons of the nucleus of the lateral lemniscus were labelled after FG injection into the PIL.

Fig. 9K

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PIL (Posterior intralaminar thalamic nucleus) MBA:560581563 projects to ZI (Zona incerta) MBA:797 · Mouse

PIL viral tracing labelled terminals in the mouse zona incerta.

Fig. 11A-D

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PIL (Posterior intralaminar thalamic nucleus) MBA:560581563 projects to CUN (Cuneiform nucleus) MBA:616 · Mouse

Weak PIL terminal labelling extended to the midbrain reticular formation including the cuneiform nucleus.

Results, efferent projections in mice

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SPF (Subparafascicular nucleus) UBERON:0016641 projects to PILN (posterior group of intralaminar nuclei) UBERON:0019295 · Rat

FG in the PIL labelled neurons in the subparafascicular nucleus on both sides.

Fig. 9H

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InL (insular lobe) UBERON:0002022 projects to PILN (posterior group of intralaminar nuclei) UBERON:0019295 · Rat

FG and BDA injections in the PIL labelled layer 5-6 neurons of the insular cortex.

Fig. 9C; Fig. 4B

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IC (Inferior colliculus) UBERON:0001946 projects to PP (Peripeduncular nucleus) UBERON:0002144 · Rat

Many IC neurons were labelled from the PP, significantly more than from the PIL.

Fig. 10E; Fig. 8E-H

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AUDd (Dorsal auditory area) UBERON:0035885 projects to PP (Peripeduncular nucleus) UBERON:0002144 · Rat

Many dorsal auditory cortex neurons were labelled by FG in the PP.

Fig. 10C

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PF (Parafascicular nucleus) UBERON:0001922 projects to PP (Peripeduncular nucleus) UBERON:0002144 · Rat

A moderate number of parafascicular neurons were FG-labelled after PP injection.

Fig. 10K

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TEa (Temporal association areas) UBERON:0035013 projects to PILN (posterior group of intralaminar nuclei) UBERON:0019295 · Rat

A few layer 5 neurons of the temporal association cortex were retrogradely labelled by the PIL BDA injection.

Fig. 4C

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PIL (Posterior intralaminar thalamic nucleus) MBA:560581563 projects to LA (Lateral amygdalar nucleus) MBA:131 · Mouse

Mouse PIL viral tracing produced strong terminal labelling in the ventral lateral amygdala.

Fig. 11B,D

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PILN (posterior group of intralaminar nuclei) UBERON:0019295 projects to VMH (Ventromedial hypothalamic nucleus) UBERON:0001935 · Rat

After FG injections into the VMH only a few labelled cells lay in the PIL.

Fig. 7B-F; Fig. 8A-D

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PIL (Posterior intralaminar thalamic nucleus) MBA:560581563 projects to MPN (Medial preoptic nucleus) MBA:515 · Mouse

The medial preoptic nucleus showed almost no PIL-derived terminals in mice.

Fig. 11A,C

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ZI (Zona incerta) UBERON:0001907 projects to PP (Peripeduncular nucleus) UBERON:0002144 · Rat

Moderate numbers of zona incerta neurons were labelled from the PP.

Fig. 10J

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SPVC (Spinal nucleus of the trigeminal, caudal part) UBERON:0002866 projects to PP (Peripeduncular nucleus) UBERON:0002144 · Rat

Few contralateral Sp5C neurons were labelled by PP FG injection.

Results, afferent projections of PP (not shown)

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SOC (Superior olivary complex) UBERON:0002128 projects to PILN (posterior group of intralaminar nuclei) UBERON:0019295 · Rat

PIL FG injections labelled cells in the superior olivary complex.

Fig. 9N

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PP (Peripeduncular nucleus) UBERON:0002144 projects to LA (lateral amygdaloid nucleus) UBERON:0002886 · Rat

PP BDA injections labelled strong terminals in the lateral ventral lateral amygdaloid nucleus.

Fig. 5C,J

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PP (Peripeduncular nucleus) UBERON:0002144 projects to MEA (medial amygdaloid nucleus) UBERON:0002892 · Rat

The medial amygdala, including its posterior part, received strong PP terminal labelling.

Fig. 5C,J

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SC (superior colliculus) UBERON:0001945 projects to PILN (posterior group of intralaminar nuclei) UBERON:0019295 · Rat

FG in the PIL labelled neurons in the ipsilateral and contralateral superior colliculus.

Fig. 9O

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PIL (Posterior intralaminar thalamic nucleus) MBA:560581563 projects to PSTN (Parasubthalamic nucleus) MBA:364 · Mouse

The parasubthalamic nucleus received weaker PIL terminal labelling.

Results, efferent projections in mice

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PILN (posterior group of intralaminar nuclei) UBERON:0019295 projects to LA (lateral amygdaloid nucleus) UBERON:0002886 · Rat

BDA in the PIL labelled dense terminals in the medial ventral lateral amygdaloid nucleus.

Fig. 4B,E,F

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LDT (Laterodorsal tegmental nucleus) UBERON:0002267 projects to PP (Peripeduncular nucleus) UBERON:0002144 · Rat

Scattered FG-labelled cells were present in the laterodorsal tegmental nucleus after PP injection.

Fig. 10 caption

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PP (Peripeduncular nucleus) UBERON:0002144 projects to IC (Inferior colliculus) UBERON:0001946 · Rat

Strong PP-derived terminal labelling occurred in the inferior colliculus.

Fig. 5H

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PP (Peripeduncular nucleus) UBERON:0002144 projects to BMA (medial part of basal amygdaloid nucleus) UBERON:0002889 · Rat

BDA in the PP labelled strong terminals in the basomedial amygdala.

Fig. 5C,J

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NB (Nucleus of the brachium of the inferior colliculus) UBERON:0036012 projects to PP (Peripeduncular nucleus) UBERON:0002144 · Rat

Labelled neurons were seen in the nucleus of the brachium of the inferior colliculus after PP FG injection.

Fig. 10F

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PIL (Posterior intralaminar thalamic nucleus) MBA:560581563 projects to ECT (Ectorhinal area) MBA:895 · Mouse

Cre-dependent viral tracing from the PIL in Calb2-Cre mice labelled terminals mainly in layers 1 and 5 of ectorhinal cortex.

Fig. 11A-D

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PP (Peripeduncular nucleus) UBERON:0002144 projects to Isocortex UBERON:0001950 · Rat

BDA in the PP labelled strong terminal fields in the ectorhinal cortex.

Fig. 5B

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PP (Peripeduncular nucleus) UBERON:0002144 projects to AHN (Anterior hypothalamic nucleus) UBERON:0002634 · Rat

Moderate density of PP-derived terminals was seen in the anterior hypothalamic nucleus.

Fig. 5F; Fig. 6D

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PIL (Posterior intralaminar thalamic nucleus) MBA:560581563 projects to BMA (Basomedial amygdalar nucleus) MBA:319 · Mouse

Weaker terminal labelling from the PIL was seen in the basomedial amygdala.

Results, efferent projections in mice

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IC (Inferior colliculus) UBERON:0001946 projects to PILN (posterior group of intralaminar nuclei) UBERON:0019295 · Rat

PIL FG injections labelled inferior colliculus neurons on both sides, fewer than after PP injections.

Fig. 9M; Fig. 8E-H

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PERI (Perirhinal area) UBERON:0006083 projects to PP (Peripeduncular nucleus) UBERON:0002144 · Rat

PP FG injections labelled many layer 5 neurons in perirhinal-ectorhinal cortex.

Fig. 10D

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LDT (Laterodorsal tegmental nucleus) MBA:162 projects to PP (Peripeduncular nucleus) MBA:1044 · Mouse

The LDTg injection labelled far fewer terminals in the PP than in the PIL.

Supplementary Fig. 3A,B

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PB (Parabrachial nucleus) UBERON:0007634 projects to PILN (posterior group of intralaminar nuclei) UBERON:0019295 · Rat

A PIL BDA injection retrogradely labelled a few cell bodies in the parabrachial nuclei.

Fig. 4K

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PP (Peripeduncular nucleus) UBERON:0002144 projects to RCH (Retrochiasmatic area) UBERON:0001933 · Rat

Weaker terminal labelling from the PP was detected in the retrochiasmatic area.

Fig. 5F

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TEa (Temporal association areas) UBERON:0035013 projects to PP (Peripeduncular nucleus) UBERON:0002144 · Rat

Some layer 5 neurons of temporal cortex were retrogradely labelled by BDA injected into the PP.

Fig. 5B

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CEA (Central amygdalar nucleus) MBA:536 projects to PP (Peripeduncular nucleus) MBA:1044 · Mouse

An anterograde tracer in the central amygdala of a wild-type mouse labelled terminals mostly in the PP.

Supplementary Fig. 3C,D

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CU (Cuneate nucleus) UBERON:0002045 projects to PILN (posterior group of intralaminar nuclei) UBERON:0019295 · Rat

Sparse FG-labelled neurons appeared in the contralateral cuneate nucleus after PIL injection.

Fig. 9B

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AUDd (Dorsal auditory area) UBERON:0035885 projects to PILN (posterior group of intralaminar nuclei) UBERON:0019295 · Rat

Layer 6 neurons of the dorsal auditory cortex were retrogradely labelled from the PIL.

Fig. 9D

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PIL (Posterior intralaminar thalamic nucleus) MBA:560581563 projects to RCH (Retrochiasmatic area) MBA:173 · Mouse

Almost no PIL terminal labelling was seen in the retrochiasmatic area.

Fig. 11A,C

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PILN (posterior group of intralaminar nuclei) UBERON:0019295 projects to BST (Bed nuclei of the stria terminalis) UBERON:0001880 · Rat

Weak terminal labelling from the PIL was shown in the bed nucleus of the stria terminalis.

Fig. 4H

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LGv (Ventral part of the lateral geniculate complex) UBERON:0002480 projects to PP (Peripeduncular nucleus) UBERON:0002144 · Rat

A moderate number of FG-labelled cells were found in the medial ventral lateral geniculate after PP injection.

Fig. 10I

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PP (Peripeduncular nucleus) UBERON:0002144 projects to GPe (Globus pallidus, external segment) UBERON:0002476 · Rat

Strong PP-derived terminals were found in the external globus pallidus.

Fig. 5C

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PILN (posterior group of intralaminar nuclei) UBERON:0019295 projects to SC (superior colliculus) UBERON:0001945 · Rat

Strong PIL-derived terminal labelling was found in the intermediate layers of the superior colliculus.

Fig. 4L

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PIL (Posterior intralaminar thalamic nucleus) MBA:560581563 projects to CP (Caudoputamen) MBA:672 · Mouse

The caudate-putamen was a main target of PIL axons in Calb2-Cre mice.

Fig. 11A-D

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