Comparison of the connectivity of the posterior intralaminar thalamic nucleus and peripeduncular nucleus in rats and mice

VMH (Ventromedial hypothalamic nucleus) UBERON:0001935 projects to PILN (posterior group of intralaminar nuclei) UBERON:0019295 · Rat

PIL FG injections labelled VMH neurons, though far fewer than PP injections did.

Fig. 9F; Fig. 8E-H

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PILN (posterior group of intralaminar nuclei) UBERON:0019295 projects to BMA (medial part of basal amygdaloid nucleus) UBERON:0002889 · Rat

PIL BDA injections labelled strong terminals in the anterior basomedial amygdala.

Fig. 4E,F

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LDT (Laterodorsal tegmental nucleus) MBA:162 projects to PIL (Posterior intralaminar thalamic nucleus) MBA:560581563 · Mouse

An anterograde injection in the LDTg of a Chat-Cre mouse labelled terminals mainly in the PIL.

Supplementary Fig. 3A,B

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ZI (Zona incerta) UBERON:0001907 projects to PILN (posterior group of intralaminar nuclei) UBERON:0019295 · Rat

Zona incerta neurons were labelled by FG injected in the PIL.

Fig. 9G

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PP (Peripeduncular nucleus) UBERON:0002144 projects to CP (Caudoputamen) UBERON:0005383 · Rat

PP BDA injections produced strong terminal labelling in the posteroventral putamen.

Fig. 5C

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PBG (Parabigeminal nucleus) UBERON:0002140 projects to PILN (posterior group of intralaminar nuclei) UBERON:0019295 · Rat

Neither BDA nor FG injections restricted to the PIL labelled any neurons in the parabigeminal nucleus.

Fig. 4M; Results, afferent projections (Fig. 9)

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CEA (central amygdaloid nucleus) UBERON:0002883 projects to PP (Peripeduncular nucleus) UBERON:0002144 · Rat

Many lateral central amygdala neurons were retrogradely labelled from the PP.

Fig. 10H

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CUN (Cuneiform nucleus) UBERON:0002696 projects to PP (Peripeduncular nucleus) UBERON:0002144 · Rat

A few contralateral cuneiform nucleus neurons were labelled from the PP.

Results, afferent projections of PP (data not shown)

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PILN (posterior group of intralaminar nuclei) UBERON:0019295 projects to MEA (medial amygdaloid nucleus) UBERON:0002892 · Rat

Only faint terminal labelling from the PIL was present in the medial amygdala.

Fig. 4F,G

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SN (substantia nigra) UBERON:0002038 projects to PP (Peripeduncular nucleus) UBERON:0002144 · Rat

Scattered labelled cells were found in the ipsilateral lateral substantia nigra after PP injection.

Fig. 10 caption

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PP (Peripeduncular nucleus) UBERON:0002144 projects to MPN (Medial preoptic nucleus) UBERON:0002035 · Rat

Terminal labelling from the PP was clearly present in the medial preoptic nucleus, unlike after PIL injections.

Fig. 5D; Fig. 6B

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CEA (Central amygdalar nucleus) MBA:536 projects to PIL (Posterior intralaminar thalamic nucleus) MBA:560581563 · Mouse

The central amygdala injection labelled many fewer terminals in the PIL than in the PP.

Supplementary Fig. 3C,D

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PP (Peripeduncular nucleus) UBERON:0002144 projects to SPF (Subparafascicular nucleus) UBERON:0016641 · Rat

PP BDA injection labelled terminals in the subparafascicular nucleus.

Fig. 5I

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PERI (Perirhinal area) UBERON:0006083 projects to PILN (posterior group of intralaminar nuclei) UBERON:0019295 · Rat

FG in the PIL labelled layer 5 neurons of perirhinal-ectorhinal cortex.

Fig. 9E

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PILN (posterior group of intralaminar nuclei) UBERON:0019295 projects to AAA (anterior amygdaloid area) UBERON:0002890 · Rat

The caption lists labelled PIL terminals in the anterior amygdaloid area, among regions with only weak labelling.

Fig. 4D

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SOC (Superior olivary complex) UBERON:0002128 projects to PP (Peripeduncular nucleus) UBERON:0002144 · Rat

Few superior olivary neurons were labelled by FG in the PP.

Results, afferent projections of PP (data not shown)

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PP (Peripeduncular nucleus) UBERON:0002144 projects to BST (Bed nuclei of the stria terminalis) UBERON:0001880 · Rat

PP BDA injection labelled axon terminals in the BST.

Fig. 5D

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GR (Gracile nucleus) UBERON:0002161 projects to PP (Peripeduncular nucleus) UBERON:0002144 · Rat

A few contralateral gracile nucleus neurons were FG-labelled after PP injection.

Results, afferent projections of PP (not shown)

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PILN (posterior group of intralaminar nuclei) UBERON:0019295 projects to PAG (Periaqueductal gray) UBERON:0003040 · Rat

Only faint PIL terminal labelling was found in the PAG.

Fig. 4L

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VMH (Ventromedial hypothalamic nucleus) UBERON:0001935 projects to PP (Peripeduncular nucleus) UBERON:0002144 · Rat

FG in the PP labelled many VMH neurons bilaterally, much more than PIL injections.

Fig. 10G; Fig. 8E-H

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SN (substantia nigra) UBERON:0002038 projects to PILN (posterior group of intralaminar nuclei) UBERON:0019295 · Rat

FG in the PIL labelled neurons in the lateral substantia nigra.

Fig. 9L

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PILN (posterior group of intralaminar nuclei) UBERON:0019295 projects to PF (Parafascicular nucleus) UBERON:0001922 · Rat

Labelled axon terminals from a PIL BDA injection were seen in the ventral parafascicular nucleus.

Fig. 4J

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GR (Gracile nucleus) UBERON:0002161 projects to PILN (posterior group of intralaminar nuclei) UBERON:0019295 · Rat

FG in the PIL sparsely labelled neurons in the contralateral gracile nucleus.

Fig. 9B

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PP (Peripeduncular nucleus) UBERON:0002144 projects to VMH (Ventromedial hypothalamic nucleus) UBERON:0001935 · Rat

PP BDA injections produced dense terminal labelling in the VMH, scored as strong.

Fig. 5E; Fig. 6C

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PPN (Pedunculopontine nucleus) UBERON:0002142 projects to PILN (posterior group of intralaminar nuclei) UBERON:0019295 · Rat

The figure caption reports FG-labelled neurons in the pedunculopontine tegmental nucleus after PIL injection.

Fig. 9K

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SC (superior colliculus) UBERON:0001945 projects to PP (Peripeduncular nucleus) UBERON:0002144 · Rat

A few superior colliculus neurons on both sides were labelled from the PP.

Results, afferent projections of PP (data not shown)

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PAG (Periaqueductal gray) UBERON:0003040 projects to PP (Peripeduncular nucleus) UBERON:0002144 · Rat

A few PAG neurons were labelled after PP FG injection.

Results, afferent projections of PP (data not shown)

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VMH (Ventromedial hypothalamic nucleus) MBA:693 projects to PP (Peripeduncular nucleus) MBA:1044 · Mouse

Viral tracer injections into the VMH of Fezf1-Cre and Nkx2-1-Cre mice gave dense terminal labelling in the PP.

Fig. 13

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PILN (posterior group of intralaminar nuclei) UBERON:0019295 projects to IC (Inferior colliculus) UBERON:0001946 · Rat

Strong terminal labelling followed PIL BDA injection in the inferior colliculus.

Fig. 4M

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PB (Parabrachial nucleus) UBERON:0007634 projects to PP (Peripeduncular nucleus) UBERON:0002144 · Rat

A few parabrachial neurons were FG-labelled after PP injection.

Results, afferent projections of PP (data not shown)

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InL (insular lobe) UBERON:0002022 projects to PP (Peripeduncular nucleus) UBERON:0002144 · Rat

FG in the PP labelled many layer 5 neurons of the insular cortex, also seen with BDA.

Fig. 10B; Fig. 5C

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PILN (posterior group of intralaminar nuclei) UBERON:0019295 projects to PB (Parabrachial nucleus) UBERON:0007634 · Rat

Faint terminal labelling from the PIL was seen in the parabrachial nuclei.

Fig. 4K

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SPF (Subparafascicular nucleus) UBERON:0016641 projects to PP (Peripeduncular nucleus) UBERON:0002144 · Rat

Subparafascicular neurons were labelled in moderate numbers by FG in the PP.

Fig. 10K

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CU (Cuneate nucleus) UBERON:0002045 projects to PP (Peripeduncular nucleus) UBERON:0002144 · Rat

A few contralateral cuneate neurons were labelled from the PP.

Results, afferent projections of PP (not shown)

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PIL (Posterior intralaminar thalamic nucleus) MBA:560581563 projects to VMH (Ventromedial hypothalamic nucleus) MBA:693 · Mouse

Almost no PIL terminal labelling was found in the VMH of Calb2-Cre mice.

Fig. 11A,C

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VMH (Ventromedial hypothalamic nucleus) MBA:693 projects to PIL (Posterior intralaminar thalamic nucleus) MBA:560581563 · Mouse

The same VMH injections produced only weak terminal labelling in the PIL.

Fig. 13B,C,E,F

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PRNc (Pontine reticular nucleus, caudal part) UBERON:0002963 projects to PILN (posterior group of intralaminar nuclei) UBERON:0019295 · Rat

Caudal pontine reticular neurons were labelled after PIL FG injection.

Fig. 9N

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PILN (posterior group of intralaminar nuclei) UBERON:0019295 projects to COA (cortical amygdaloid nucleus) UBERON:0002891 · Rat

Weak BDA terminal labelling from the PIL appeared in the cortical amygdala.

Fig. 4D

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PILN (posterior group of intralaminar nuclei) UBERON:0019295 projects to ZI (Zona incerta) UBERON:0001907 · Rat

BDA in the PIL labelled axon terminals in the zona incerta.

Fig. 4J

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PILN (posterior group of intralaminar nuclei) UBERON:0019295 projects to VMH (Ventromedial hypothalamic nucleus) UBERON:0001935 · Rat

PIL BDA injections produced sparse terminal labelling in the VMH, scored as weak.

Fig. 4I; Fig. 6A

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PILN (posterior group of intralaminar nuclei) UBERON:0019295 projects to GPe (Globus pallidus, external segment) UBERON:0002476 · Rat

BDA in the PIL produced strong terminal labelling in the GPe next to the posteroventral putamen.

Fig. 4B

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PIL (Posterior intralaminar thalamic nucleus) MBA:560581563 projects to MEA (Medial amygdalar nucleus) MBA:403 · Mouse

Weaker PIL terminal labelling was present in the anterior and posterior medial amygdala.

Results, efferent projections in mice

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RT (Reticular nucleus of the thalamus) UBERON:0001903 projects to PILN (posterior group of intralaminar nuclei) UBERON:0019295 · Rat

FG in the PIL labelled cells in the reticular thalamic nucleus.

Fig. 9I

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PP (Peripeduncular nucleus) UBERON:0002144 projects to VMH (Ventromedial hypothalamic nucleus) UBERON:0001935 · Rat

FG injected into the VMH labelled many neurons throughout the PP, significantly more than in the PIL.

Fig. 7; Fig. 8A-D

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GPe (Globus pallidus, external segment) UBERON:0002476 projects to PP (Peripeduncular nucleus) UBERON:0002144 · Rat

The figure shows FG-labelled cells in the external globus pallidus after PP injection.

Fig. 10H

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PILN (posterior group of intralaminar nuclei) UBERON:0019295 projects to CP (Caudoputamen) UBERON:0005383 · Rat

A BDA injection confined to the PIL labelled many axon terminals in the posteroventral putamen, which the caption ranks among the strongly labelled targets.

Fig. 4B; Results, efferent projections in rats

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LHA (Lateral hypothalamic area) UBERON:0002430 projects to PP (Peripeduncular nucleus) UBERON:0002144 · Rat

FG-labelled cells appeared in the lateral hypothalamus after PP injection.

Fig. 10G

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PILN (posterior group of intralaminar nuclei) UBERON:0019295 projects to SPF (Subparafascicular nucleus) UBERON:0016641 · Rat

PIL BDA injection labelled terminals in the subparafascicular nucleus.

Fig. 4J

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PILN (posterior group of intralaminar nuclei) UBERON:0019295 projects to MPN (Medial preoptic nucleus) UBERON:0002035 · Rat

The medial preoptic nucleus showed only faint terminal labelling after PIL BDA injection.

Fig. 4H

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PILN (posterior group of intralaminar nuclei) UBERON:0019295 projects to LZ (Hypothalamic lateral zone) UBERON:0002273 · Rat

Terminals labelled from the PIL were found in the parasubthalamic nucleus of the lateral hypothalamic zone.

Fig. 4J

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