Whole-Brain Neural Connectivity to Lateral Pontine Tegmentum GABAergic Neurons in Mice

ACB (Nucleus accumbens) MBA:56 synapses onto P (Pons) MBA:771 · Mouse

Nucleus accumbens neurons were labelled as monosynaptic inputs to LPT GABAergic neurons.

Fig. 4

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TM (Tuberomammillary nucleus) MBA:557 synapses onto P (Pons) MBA:771 · Mouse

Tuberomammillary nucleus neurons were labelled as inputs to LPT GABAergic neurons.

Fig. 3, 4

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RN (Red nucleus) MBA:214 synapses onto P (Pons) MBA:771 · Mouse

Red nucleus neurons were labelled as inputs to LPT GABAergic neurons.

Fig. 4, 6

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P (Pons) MBA:771 projects to BMA (Basomedial amygdalar nucleus) MBA:319 · Mouse

The basomedial amygdala received at least 0.1% of LPT GABAergic varicosities.

Fig. 9

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P (Pons) MBA:771 projects to ACB (Nucleus accumbens) MBA:56 · Mouse

LPT GABAergic axons innervated the nucleus accumbens.

Fig. 8

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PSTN (Parasubthalamic nucleus) MBA:364 synapses onto P (Pons) MBA:771 · Mouse

The parasubthalamic nucleus provided monosynaptic inputs to LPT GABAergic neurons, and about 44% of these input cells were calretinin-positive.

Fig. 4, 5C, 6

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V (Motor nucleus of trigeminal) MBA:621 synapses onto P (Pons) MBA:771 · Mouse

The motor trigeminal nucleus contained inputs to LPT GABAergic neurons.

Fig. 4, 6

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MO (Somatomotor areas) MBA:500 synapses onto P (Pons) MBA:771 · Mouse

Rabies-labelled input neurons to LPT GABAergic cells were found in somatomotor cortex.

Fig. 3, 6

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

P (Pons) MBA:771 projects to LHA (Lateral hypothalamic area) MBA:194 · Mouse

The LHA received about 8.1% of LPT GABAergic axonal varicosities.

Fig. 8, 9

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BST (Bed nuclei of the stria terminalis) MBA:351 synapses onto P (Pons) MBA:771 · Mouse

The BNST provided monosynaptic inputs to LPT GABAergic neurons, and about 32% of these input cells were GABA-positive.

Fig. 4, 5D, 6

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LHA (Lateral hypothalamic area) MBA:194 synapses onto P (Pons) MBA:771 · Mouse

The LHA provided monosynaptic inputs to LPT GABAergic neurons. Some of these input cells were orexin-positive (about 14%) and some MCH-positive (about 11%).

Fig. 4, 5A-B, 6

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P (Pons) MBA:771 projects to MEA (Medial amygdalar nucleus) MBA:403 · Mouse

The medial amygdala received at least 0.1% of LPT GABAergic varicosities.

Fig. 9

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P (Pons) MBA:771 projects to PF (Parafascicular nucleus) MBA:930 · Mouse

LPT GABAergic axons innervated the parafascicular thalamic nucleus.

Fig. 8, 9

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GRN (Gigantocellular reticular nucleus) MBA:1048 synapses onto P (Pons) MBA:771 · Mouse

Gigantocellular reticular nucleus neurons were labelled as inputs to LPT GABAergic neurons.

Fig. 3, 4, 6

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DR (Dorsal nucleus raphe) MBA:872 synapses onto P (Pons) MBA:771 · Mouse

The dorsal raphe was the third-largest source of monosynaptic inputs to LPT GABAergic neurons. About 20% of the DR input cells were serotonergic.

Fig. 4, 5F, 6

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PALd (Pallidum, dorsal region) MBA:818 synapses onto P (Pons) MBA:771 · Mouse

The dorsal pallidum contained inputs to LPT GABAergic neurons.

Fig. 3, 6

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MB (Midbrain) MBA:313 synapses onto P (Pons) MBA:771 · Mouse

Monosynaptic rabies tracing from LPT GABAergic neurons in GAD2-Cre mice labelled the most input neurons in the superior colliculus, including its intermediate layers.

Fig. 3, 4, 6

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) disagrees. “The subject is coded as the whole midbrain, but the paper's value refers specifically to the superior colliculus.”

P (Pons) MBA:771 projects to PSTN (Parasubthalamic nucleus) MBA:364 · Mouse

LPT GABAergic axons innervated the parasubthalamic nucleus.

Fig. 8, 9

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P (Pons) MBA:771 projects to STRv (Striatum ventral region) MBA:493 · Mouse

LPT GABAergic axon varicosities were detected in the ventral striatum.

Fig. 8, 9

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STRv (Striatum ventral region) MBA:493 synapses onto P (Pons) MBA:771 · Mouse

The ventral striatum contained rabies-labelled inputs to LPT GABAergic neurons.

Fig. 3, 4, 6

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

PAG (Periaqueductal gray) MBA:795 synapses onto P (Pons) MBA:771 · Mouse

PAG neurons were labelled as monosynaptic inputs to LPT GABAergic neurons.

Fig. 4, 6

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P (Pons) MBA:771 projects to LC (Locus ceruleus) MBA:147 · Mouse

The locus coeruleus received LPT GABAergic innervation.

Fig. 8, 9

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PB (Parabrachial nucleus) MBA:867 synapses onto P (Pons) MBA:771 · Mouse

Parabrachial nucleus neurons (lateral and medial parts) were labelled as inputs to LPT GABAergic neurons.

Fig. 3, 4, 6

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RM (Nucleus raphe magnus) MBA:206 synapses onto P (Pons) MBA:771 · Mouse

Raphe magnus neurons were labelled as inputs to LPT GABAergic neurons.

Fig. 3, 4, 6

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P (Pons) MBA:771 projects to SLD (Sublaterodorsal nucleus) MBA:358 · Mouse

The sublaterodorsal nucleus received LPT GABAergic innervation.

Fig. 8, 9

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VTA (Ventral tegmental area) MBA:749 synapses onto P (Pons) MBA:771 · Mouse

VTA neurons were labelled as monosynaptic inputs to LPT GABAergic neurons.

Fig. 3, 4, 6

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P (Pons) MBA:771 projects to PVT (Paraventricular nucleus of the thalamus) MBA:149 · Mouse

LPT GABAergic axons innervated the paraventricular thalamus.

Fig. 8, 9

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RR (Midbrain reticular nucleus, retrorubral area) MBA:246 synapses onto P (Pons) MBA:771 · Mouse

Retrorubral field neurons were labelled as inputs to LPT GABAergic neurons.

Fig. 3, 6

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

CEA (Central amygdalar nucleus) MBA:536 synapses onto P (Pons) MBA:771 · Mouse

The central amygdala provided monosynaptic inputs to LPT GABAergic neurons, and about 41% of these input cells were GABA-immunoreactive.

Fig. 4, 5E, 6

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BMA (Basomedial amygdalar nucleus) MBA:319 synapses onto P (Pons) MBA:771 · Mouse

The basomedial amygdala contained monosynaptic inputs to LPT GABAergic neurons.

Fig. 3, 4, 6

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SS (Somatosensory areas) MBA:453 synapses onto P (Pons) MBA:771 · Mouse

Somatosensory cortex contained input neurons labelled from LPT GABAergic starter cells.

Fig. 3, 6

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P (Pons) MBA:771 projects to RN (Red nucleus) MBA:214 · Mouse

The red nucleus received LPT GABAergic varicosities.

Fig. 9

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PARN (Parvicellular reticular nucleus) MBA:852 synapses onto P (Pons) MBA:771 · Mouse

The parvicellular reticular nucleus contributed inputs to LPT GABAergic neurons.

Fig. 6

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MEA (Medial amygdalar nucleus) MBA:403 synapses onto P (Pons) MBA:771 · Mouse

Medial amygdala neurons were labelled as inputs to LPT GABAergic neurons.

Fig. 3

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PRNr (Pontine reticular nucleus) MBA:146 synapses onto P (Pons) MBA:771 · Mouse

Pontine reticular nucleus neurons were labelled as inputs to LPT GABAergic neurons.

Fig. 3, 4, 6

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IC (Inferior colliculus) MBA:4 synapses onto P (Pons) MBA:771 · Mouse

The inferior colliculus contributed inputs to LPT GABAergic neurons.

Fig. 6

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PCG (Pontine central gray) MBA:898 synapses onto P (Pons) MBA:771 · Mouse

The central gray of the pons contained inputs to LPT GABAergic neurons.

Fig. 3, 6

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NLL (Nucleus of the lateral lemniscus) MBA:612 synapses onto P (Pons) MBA:771 · Mouse

Nuclei of the lateral lemniscus contained inputs to LPT GABAergic neurons.

Fig. 3, 6

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P (Pons) MBA:771 projects to PAG (Periaqueductal gray) MBA:795 · Mouse

Cre-dependent ChR2-mCherry tracing of LPT GABAergic neurons found the largest share of axonal varicosities in vlPAG (about 11.7%), with fewer in lPAG (1.4%) and dPAG (0.5%).

Fig. 8, 9

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P (Pons) MBA:771 projects to RR (Midbrain reticular nucleus, retrorubral area) MBA:246 · Mouse

The retrorubral field received LPT GABAergic varicosities.

Fig. 9

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

P (Pons) MBA:771 projects to VTA (Ventral tegmental area) MBA:749 · Mouse

LPT GABAergic axons innervated the VTA.

Fig. 8, 9

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P (Pons) MBA:771 projects to CS (Superior central nucleus raphe) MBA:679 · Mouse

The median raphe received LPT GABAergic varicosities.

Fig. 9

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P (Pons) MBA:771 projects to BLA (Basolateral amygdalar nucleus) MBA:295 · Mouse

The basolateral amygdala received at least 0.1% of LPT GABAergic varicosities.

Fig. 9

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

MEZ (Hypothalamic medial zone) MBA:467 synapses onto P (Pons) MBA:771 · Mouse

The medial hypothalamic area contained input neurons to LPT GABAergic cells.

Fig. 3, 6

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

P (Pons) MBA:771 projects to RM (Nucleus raphe magnus) MBA:206 · Mouse

The raphe magnus received LPT GABAergic varicosities.

Fig. 9

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P (Pons) MBA:771 projects to PPN (Pedunculopontine nucleus) MBA:1052 · Mouse

The pedunculopontine tegmental nucleus received LPT GABAergic varicosities.

Fig. 9

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BLA (Basolateral amygdalar nucleus) MBA:295 synapses onto P (Pons) MBA:771 · Mouse

Basolateral amygdala neurons were labelled as inputs to LPT GABAergic neurons.

Fig. 4

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PRT (Pretectal region) MBA:1100 synapses onto P (Pons) MBA:771 · Mouse

The pretectal region contributed inputs to LPT GABAergic neurons.

Fig. 6

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PVT (Paraventricular nucleus of the thalamus) MBA:149 synapses onto P (Pons) MBA:771 · Mouse

The paraventricular thalamus contributed inputs to LPT GABAergic neurons.

Fig. 6

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CUN (Cuneiform nucleus) MBA:616 synapses onto P (Pons) MBA:771 · Mouse

The cuneiform nucleus contributed inputs to LPT GABAergic neurons.

Fig. 6

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