Whole-Brain Neural Connectivity to Lateral Pontine Tegmentum GABAergic Neurons in Mice

P (Pons) MBA:771 projects to MD (Mediodorsal nucleus of thalamus) MBA:362 · Mouse

Medial thalamus (mediodorsal and central medial nuclei combined) received about 3.9% of LPT GABAergic varicosities.

Fig. 7C, 8, 9

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

SNc (Substantia nigra, compact part) MBA:374 synapses onto P (Pons) MBA:771 · Mouse

SNc neurons provided monosynaptic inputs to LPT GABAergic neurons.

Fig. 6

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

P (Pons) MBA:771 projects to CEA (Central amygdalar nucleus) MBA:536 · Mouse

LPT GABAergic varicosities were found in the central amygdala.

Fig. 8, 9

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

SLD (Sublaterodorsal nucleus) MBA:358 synapses onto P (Pons) MBA:771 · Mouse

Sublaterodorsal nucleus neurons were labelled as inputs to LPT GABAergic neurons.

Fig. 3, 4, 6

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

VNC (Vestibular nuclei) MBA:701 synapses onto P (Pons) MBA:771 · Mouse

Vestibular nucleus neurons were labelled as inputs to LPT GABAergic neurons.

Fig. 3, 6

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

MRN (Midbrain reticular nucleus) MBA:128 synapses onto P (Pons) MBA:771 · Mouse

The deep mesencephalic nucleus provided a substantial share of the rabies-labelled inputs to LPT GABAergic neurons.

Fig. 6

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

P (Pons) MBA:771 projects to NLL (Nucleus of the lateral lemniscus) MBA:612 · Mouse

The nuclei of the lateral lemniscus received LPT GABAergic varicosities.

Fig. 9

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

ZI (Zona incerta) MBA:797 synapses onto P (Pons) MBA:771 · Mouse

Zona incerta neurons were labelled as inputs to LPT GABAergic neurons.

Fig. 3, 4, 6

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

P (Pons) MBA:771 projects to PARN (Parvicellular reticular nucleus) MBA:852 · Mouse

The parvicellular reticular nucleus received LPT GABAergic innervation.

Fig. 8, 9

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

STRd (Striatum dorsal region) MBA:485 synapses onto P (Pons) MBA:771 · Mouse

The dorsal striatum contained input neurons to LPT GABAergic cells.

Fig. 6

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

P (Pons) MBA:771 projects to MB (Midbrain) MBA:313 · Mouse

The superior colliculus received about 4.6% of LPT GABAergic axonal varicosities.

Fig. 8, 9

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) disagrees. “The object is coded as the whole midbrain, but the 4.6% value is for the superior colliculus specifically.”

P (Pons) MBA:771 projects to SNc (Substantia nigra, compact part) MBA:374 · Mouse

LPT GABAergic axons innervated the substantia nigra pars compacta.

Fig. 8, 9

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

AI (Agranular insular area) MBA:95 synapses onto P (Pons) MBA:771 · Mouse

Agranular insular cortex supplied more than 0.1% of the inputs to LPT GABAergic neurons.

Fig. 6

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

P (Pons) MBA:771 projects to GRN (Gigantocellular reticular nucleus) MBA:1048 · Mouse

The gigantocellular reticular nucleus received LPT GABAergic varicosities.

Fig. 9

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

LDT (Laterodorsal tegmental nucleus) MBA:162 synapses onto P (Pons) MBA:771 · Mouse

Laterodorsal tegmental nucleus neurons were labelled as inputs to LPT GABAergic neurons.

Fig. 3, 4, 6

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

IRN (Intermediate reticular nucleus) MBA:136 synapses onto P (Pons) MBA:771 · Mouse

The intermediate reticular nucleus contributed inputs to LPT GABAergic neurons.

Fig. 6

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

P (Pons) MBA:771 projects to MEZ (Hypothalamic medial zone) MBA:467 · Mouse

The medial hypothalamic area received about 5.1% of LPT GABAergic varicosities.

Fig. 8, 9

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

P (Pons) MBA:771 projects to PRNr (Pontine reticular nucleus) MBA:146 · Mouse

The pontine reticular nucleus received LPT GABAergic varicosities.

Fig. 9

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

P (Pons) MBA:771 projects to BST (Bed nuclei of the stria terminalis) MBA:351 · Mouse

LPT GABAergic axonal varicosities were found in the BNST.

Fig. 8, 9

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

P (Pons) MBA:771 projects to PSV (Principal sensory nucleus of the trigeminal) MBA:7 · Mouse

The principal sensory trigeminal nucleus received LPT GABAergic varicosities.

Fig. 9

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

P (Pons) MBA:771 projects to PALv (Pallidum, ventral region) MBA:835 · Mouse

LPT GABAergic axons reached the ventral pallidum.

Fig. 8, 9

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

P (Pons) MBA:771 projects to IRN (Intermediate reticular nucleus) MBA:136 · Mouse

The intermediate reticular nucleus received LPT GABAergic innervation.

Fig. 8, 9

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

P (Pons) MBA:771 projects to DR (Dorsal nucleus raphe) MBA:872 · Mouse

The DR received about 6.4% of LPT GABAergic varicosities, roughly matching its share of inputs, which makes the connection reciprocal.

Fig. 8, 9, 10B

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

P (Pons) MBA:771 projects to PB (Parabrachial nucleus) MBA:867 · Mouse

The parabrachial nuclei received about 8.8% of LPT GABAergic varicosities.

Fig. 8, 9

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

CBN (Cerebellar nuclei) MBA:519 synapses onto P (Pons) MBA:771 · Mouse

A few labelled input neurons were found in the deep cerebellar nuclei.

Fig. 3, 6

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

PF (Parafascicular nucleus) MBA:930 synapses onto P (Pons) MBA:771 · Mouse

Parafascicular thalamic neurons were labelled as inputs to LPT GABAergic neurons.

Fig. 3, 4, 6

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

P (Pons) MBA:771 projects to STN (Subthalamic nucleus) MBA:470 · Mouse

LPT GABAergic axons innervated the subthalamic nucleus.

Fig. 8

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

P (Pons) MBA:771 projects to ZI (Zona incerta) MBA:797 · Mouse

LPT GABAergic axons innervated the zona incerta.

Fig. 8, 9

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

LC (Locus ceruleus) MBA:147 synapses onto P (Pons) MBA:771 · Mouse

Locus coeruleus neurons were labelled as inputs to LPT GABAergic neurons.

Fig. 3, 6

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

P (Pons) MBA:771 projects to VNC (Vestibular nuclei) MBA:701 · Mouse

The vestibular nucleus received LPT GABAergic varicosities.

Fig. 9

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

P (Pons) MBA:771 projects to MRN (Midbrain reticular nucleus) MBA:128 · Mouse

LPT GABAergic axons innervated the deep mesencephalic nucleus.

Fig. 8, 9

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

STN (Subthalamic nucleus) MBA:470 synapses onto P (Pons) MBA:771 · Mouse

Subthalamic nucleus neurons were labelled as inputs to LPT GABAergic neurons.

Fig. 4, 6

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

P (Pons) MBA:771 projects to PCG (Pontine central gray) MBA:898 · Mouse

The central gray of the pons received LPT GABAergic varicosities.

Fig. 9

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

PPN (Pedunculopontine nucleus) MBA:1052 synapses onto P (Pons) MBA:771 · Mouse

The pedunculopontine tegmental nucleus contributed inputs to LPT GABAergic neurons.

Fig. 6

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

PSV (Principal sensory nucleus of the trigeminal) MBA:7 synapses onto P (Pons) MBA:771 · Mouse

The principal sensory trigeminal nucleus contributed inputs to LPT GABAergic neurons.

Fig. 6

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

P (Pons) MBA:771 projects to CUN (Cuneiform nucleus) MBA:616 · Mouse

The cuneiform nucleus received LPT GABAergic varicosities.

Fig. 9

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

PALv (Pallidum, ventral region) MBA:835 synapses onto P (Pons) MBA:771 · Mouse

The ventral pallidum contained inputs to LPT GABAergic neurons.

Fig. 3, 6

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

CS (Superior central nucleus raphe) MBA:679 synapses onto P (Pons) MBA:771 · Mouse

The median raphe contributed inputs to LPT GABAergic neurons.

Fig. 6

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

P (Pons) MBA:771 projects to LDT (Laterodorsal tegmental nucleus) MBA:162 · Mouse

The laterodorsal tegmental nucleus received LPT GABAergic varicosities.

Fig. 9

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

SNr (Substantia nigra, reticular part) MBA:381 synapses onto P (Pons) MBA:771 · Mouse

The SNr was the second-largest source of rabies-labelled inputs to LPT GABAergic neurons. About 65% of these inputs were parvalbumin-positive.

Fig. 4, 5G, 6

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

P (Pons) MBA:771 projects to V (Motor nucleus of trigeminal) MBA:621 · Mouse

The motor trigeminal nucleus received LPT GABAergic varicosities.

Fig. 9

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

GPi (Globus pallidus, internal segment) MBA:1031 synapses onto P (Pons) MBA:771 · Mouse

Medial globus pallidus neurons were labelled as inputs to LPT GABAergic neurons.

Fig. 4

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.