Deletion of ErbB4 Disrupts Synaptic Transmission and Long-Term Potentiation of Thalamic Input to Amygdalar Medial Paracapsular Intercalated Cells

int (internal capsule) MBA:6 functionally connects to Intercalated cell GABAergic neurons nt-y231zwbxhf · Mouse

Bipolar electrical stimulation of thalamic fibres in the internal capsule evoked EPSPs in medial paracapsular intercalated cells; pairing this stimulation with postsynaptic depolarization produced long-term potentiation in wild-type mice but long-term depression in ErbB4 conditional knockouts.

Fig. 4A–F

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PIL (Posterior intralaminar thalamic nucleus) MBA:560581563 projects to LA (Lateral amygdalar nucleus) MBA:131 · Mouse

After AAV-ChR2-eYFP was injected into the posterior intralaminar/medial geniculate thalamic region, eYFP-labelled axon terminals were visible in the lateral amygdala.

Fig. 2A–B; Results, section 'Thalamic Input-Driven Inhibition Onto mpITCs Is Enhanced in ErbB4 cKO Mice'

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PIL (Posterior intralaminar thalamic nucleus) MBA:560581563 functionally connects to Intercalated cell GABAergic neurons nt-y231zwbxhf · Mouse

Blue-light activation of ChR2-expressing thalamic terminals evoked glutamatergic EPSCs in patched medial paracapsular intercalated cells, with AMPA receptor-mediated currents isolated at -70 mV in bicuculline and NMDA receptor-mediated currents isolated with NBQX; responses were graded with light intensity in both genotypes.

Fig. 2D,E; Fig. 3A,D,E

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PIL (Posterior intralaminar thalamic nucleus) MBA:560581563 projects to IA (Intercalated amygdalar nucleus) MBA:1105 · Mouse

Viral anterograde labelling from the posterior intralaminar/medial geniculate thalamus produced eYFP-positive fibres within the medial paracapsular intercalated cell cluster.

Fig. 2A,C

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PIL (Posterior intralaminar thalamic nucleus) MBA:560581563 functionally connects to Intercalated cell GABAergic neurons nt-y231zwbxhf · Mouse

Optogenetic stimulation of thalamic terminals also elicited excitation-driven GABAergic IPSCs recorded at 0 mV in medial paracapsular intercalated cells; these inhibitory responses were larger in ErbB4 conditional knockouts, lowering the excitation/inhibition ratio.

Fig. 2D,F,G

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