Kölliker–Fuse/Parabrachial Complex PACAP—Glutamate Pathway to the Extended Amygdala Couples Rapid Autonomic and Delayed Endocrine Responses to Acute Hypotension

PB (Parabrachial nucleus) UBERON:0007634 projects to MY (Medulla) UBERON:0001896 · Rat

Camera lucida reconstruction of the single neurobiotin-filled KF neuron showed, in addition to the rostral forebrain branch, axon branches descending medially and caudally toward the medulla.

Fig. 5A,F

Made by an AI model reading the paper (claude-opus-5, extract@0.3.0); a second AI model (claude-opus-5) agrees.

PB (Parabrachial nucleus) UBERON:0007634 projects to BST (Bed nuclei of the stria terminalis) UBERON:0001880 · Rat

The same juxtacellularly labelled KF neuron sent a rostral axonal branch through the dorsal tegmental bundle and ansa peduncularis, ending in ring-like perisomatic (calyceal-like) terminals in the oval subdivision of the bed nucleus of the stria terminalis.

Results (juxtacellular labeling section); Fig. 5A,D,F

Made by an AI model reading the paper (claude-opus-5, extract@0.3.0); a second AI model (claude-opus-5) agrees.

PB (Parabrachial nucleus) UBERON:0007634 projects to CEA (central amygdaloid nucleus) UBERON:0002883 · Rat

A single KF neuron filled with neurobiotin in vivo had an axon that entered the superior cerebellar peduncle and gave rise to labelled terminals in the capsular central amygdala; the labelled terminals in CeC were apposed to PACAP-immunoreactive perisomatic profiles. Only one of 14 attempted recordings yielded a fully labelled KF neuron.

Results (juxtacellular labeling section); Fig. 5A,C,E,F

Made by an AI model reading the paper (claude-opus-5, extract@0.3.0); a second AI model (claude-opus-5) agrees.