The integration of Gaussian noise by long-range amygdala inputs in frontal circuit promotes fear learning in mice

BLA (Basolateral amygdalar nucleus) MBA:295 projects to Isocortex MBA:315 · Mouse

Retrograde CAV2-Cre was injected into the FrA together with Cre-dependent ArchT-GFP or GFP in the BLA. Labelled FrA-projecting neurons were found throughout the BLA.

Fig. 6A,B

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LA (Lateral amygdalar nucleus) MBA:131 projects to Isocortex MBA:315 · Mouse

After retrograde CAV2-Cre in the FrA combined with Cre-dependent GFP in the amygdala, no GFP-expressing neurons were found in the lateral amygdala.

Fig. 6B

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BLA (Basolateral amygdalar nucleus) MBA:295 projects to PL (Prelimbic area) MBA:972 · Mouse

The FrA-projecting subset of BLA neurons, labelled intersectionally, sent no GFP axon collaterals to the prelimbic cortex. This applies to that subpopulation only, not to BLA neurons as a whole.

Fig. 6C,D

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BLA (Basolateral amygdalar nucleus) MBA:295 projects to ILA (Infralimbic area) MBA:44 · Mouse

The FrA-projecting subset of BLA neurons, labelled intersectionally, showed no GFP axons in the infralimbic cortex.

Fig. 6C,D

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BLA (Basolateral amygdalar nucleus) MBA:295 functionally connects to Isocortex MBA:315 · Mouse

In slices, light activation of ChR2-expressing BLA axons evoked short-latency, low-jitter EPSCs in FrA L2/3 pyramidal neurons, consistent with a monosynaptic connection. In vivo, photostimulating BLA produced depolarizations in every recorded FrA neuron, although these responses were weak and variable.

Figure 5—figure supplement 1D–G; Fig. 5B,C

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BLA (Basolateral amygdalar nucleus) MBA:295 projects to Isocortex MBA:315 · Mouse

Viral expression of ChR2-YFP or GCaMP6f in the BLA labelled axons that reached the ipsilateral FrA. These axons were concentrated in superficial layer 1, within about 150 µm of the pia.

Fig. 4B; Fig. 5A; Figure 5—figure supplement 1A–C; Figure 4—figure supplement 1A

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BLA (Basolateral amygdalar nucleus) MBA:295 projects to MOs (Secondary motor area) MBA:993 · Mouse

BLA neurons were labelled intersectionally through their FrA projection. GFP-expressing axons from these neurons were seen in M2 as well as in the FrA.

Fig. 6C,D

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.