A bidirectional corticoamygdala circuit for the encoding and retrieval of detailed reward memories

BLA (basal amygdaloid nucleus) UBERON:0002887 projects to Isocortex UBERON:0001950 · Rat

Unilateral AAV-hSyn-hM4Di-mCherry injection into the BLA produced mCherry-labelled BLA axons and terminals in the lOFC near the guide cannula, confirmed with immunohistochemical amplification.

Fig. 5c; Fig. 5—figure supplement 1b

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5) agrees.

Isocortex UBERON:0001950 projects to BLA (basal amygdaloid nucleus) UBERON:0002887 · Rat

After AAV-CaMKIIa-ArchT-eYFP injection into the lOFC, eYFP-labelled lOFC axons and terminals were found by immunofluorescence in the BLA near the implanted optical fibers.

Fig. 4c-d; Fig. 5c

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5) agrees.

Isocortex UBERON:0001950 functionally connects to BLA (basal amygdaloid nucleus) UBERON:0002887 · Rat

In slices, green-light silencing of ArchT-expressing lOFC axons and terminals in the BLA lowered the frequency of spontaneous EPSCs (recorded under GABAA blockade) in most recorded BLA neurons, indicating excitatory lOFC drive onto BLA cells.

Fig. 4—figure supplement 1

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5) agrees.