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PB (Parabrachial nucleus) functionally connects to Rat central amygdala corticotropin-releasing hormone-expressing neurons

All claims for this connection
Species
Rat
Result
present
Method
optogenetic circuit mapping
Sign
excitatory
Evidence
Blue-light activation of ChR2-expressing PB terminals in slices from Crh-Cre rats evoked EPSCs in every mCherry-labelled CeA CRF neuron tested. AP5/CNQX blocked these EPSCs. The same stimulation also evoked glutamate-dependent feedforward IPSCs that bicuculline blocked; yellow light evoked no response.
Measurements
  • connection probability: 1, n = 8
Source

Kappa Opioid Receptor Blockade in the Amygdala Mitigates Pain Like-Behaviors by Inhibiting Corticotropin Releasing Factor Neurons in a Rat Model of Functional Pain

Frontiers in Pharmacology, 2022

DOI 10.3389/fphar.2022.903978 · PubMed 35694266 · PMC9177060, Fig. 6D,E; Results 2.4

Licence: CC-BY-4.0

Named in the paper
“parabrachial nucleus (PB)” and “CeA-CRF neurons”
Made by
an AI model reading the paper (claude-opus-5-5, extract@0.3.0), 2026-10-10
Checked by

a second AI model (claude-opus-5-5) agrees, 2026-10-10

“Optical stimulation of ChR2-expressing PB terminals evoked glutamatergic EPSCs and feedforward IPSCs in all CeA-CRF neurons tested; the caption gives n = 8 optical.”

Status

proposed

Drafted and checked by AI models; it stays proposed until people have audited a sample of such claims.