clm-69ftc4zcde
PB (Parabrachial nucleus) functionally connects to CEAc (Central amygdalar nucleus, capsular part)
All claims for this connection- Species
- Mouse
- Result
- present
- Method
- optogenetic circuit mapping
- Sign
- excitatory
- Evidence
- In slices, light activation of ChR2-expressing PBelo CGRP axons in the CeAlc evoked excitatory postsynaptic currents and raised firing in CeAlc neurons; both responses were abolished by CNQX and APV, indicating glutamatergic transmission. In vivo photostimulation of either the PBelo cell bodies or their CeAlc terminals increased Fos in the CeAlc.
- Measurements
- connection probability: 0.44, n = 25
- Source
Genetic identification of a neural circuit that suppresses appetite
Nature, 2013
DOI 10.1038/nature12596 · PubMed 24121436 · PMC3878302, Fig. 4b; Supplementary Fig. 14- Named in the paper
- “PBelo (CGRP neurons)” and “CeAlc”
- Made by
- an AI model reading the paper (claude-opus-5, extract@0.3.0), 2026-10-09
- Checked by
a second AI model (claude-opus-5) agrees, 2026-10-09
“Slice optogenetics gave CNQX/APV-sensitive EPSCs in 11/25 CeAlc cells, matching 0.44 with n=25.”
- Status
proposed
Drafted and checked by AI models; it stays proposed until people have audited a sample of such claims.